beta cell

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Related to Beta-cell: Islet of Langerhans

beta cell

n.
1. Any of the insulin-producing cells of the islets of Langerhans in the pancreas.
2. Any of the basophilic chromophil cells located in the anterior lobe of the pituitary gland.

beta cell

A pancreatic endocrine cell that comprises up to 80% of the cells in the islets of Langerhans, which produces and releases insulin. Beta cells are destroyed or dysfunctional in type-1 diabetes, function suboptimally in type-2 diabetes and become neoplastic in insulinomas. Beta cells were once distinguished solely on the basis of differential staining from other cells designated A, C and D

beta cell

1. Any of the insulin-secreting cells of the pancreas that constitute the bulk of the islets of Langerhans. Synonym: B cell
2. A basophil cell of the adenohypophysis (anterior pituitary gland).
See also: cell
References in periodicals archive ?
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.
A total of 766 patients who were not categorised to be "at risk" of developing diabetes by conventional methods were detected with one or more biomarkers of IR or beta-cell dysfunction.
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
The researchers tried adding S961 directly to mouse beta-cells in the lab, but there was no observed effect.
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kina se-4 activity.
Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.
The researchers say the their research could ultimately result in the creation of an unlimited supply of beta-cells (the insulin-producing part of pancreatic islet cells) for transplantation into people with diabetes.
We conclude that suppression of endogenous insulin by intensive, continuous insulin treatment during the first two weeks after the diagnosis of (insulin-dependent diabetes melitus) may improve beta-cell function during the subsequent year," the authors wrote.
The patent application covers pharmaceutical compositions and methods for restoring beta-cell mass and function.
First, vascular endothelial growth factor A (VEGF-A) is important for development of the islets' blood supply and for beta-cell proliferation.
An EU-funded research project ('HumEn'), in which Lickert and his team are participating, shall provide further insights in the field of beta-cell replacement therapy.
Progressive loss of beta-cell function and mass precludes use of incretin therapies in the late insulin-secreting stage of type 2 diabetes.