Beta 2-microglobulin

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Beta 2-microglobulin

Protein produced by B-cells; high concentrations in the blood are indicative of multiple myeloma.
Mentioned in: Multiple Myeloma
References in periodicals archive ?
Urinary beta-2 microglobulin and alpha-1 microglobulin are useful screening markers for tenofovir-induced kidney tubulopathy in patients with HIV-1 infection: a diagnostic accuracy study.
The serum total protein level was decreased (52 g/L; normal range 65-85 g/L) and beta-2 microglobulin level was elevated (6.3 mg/L; normal range <2 mg/L).
Studies usually done when suspecting myeloma include serum and urine electrophoresis, serum-free light chain assay, bone marrow aspiration and biopsy with karyotype and FISH analysis, measurement of serum levels of beta-2 microglobulin, albumin, and LDH, and imaging, including skeletal survey, MRI, CT, and/or PET.
Elevated salivary beta-2 microglobulin (sB2M) has been already reported in both primary Sjogren's syndrome (pSS) and secondary SS (sSS).
Beta-2 microglobulin is a strong prognostic factor in patients with DLBCL receiving R-CHOP therapy.
In contrast, nonclassical major histocompatibility complex (MHC) class I chain related (MIC) molecules show homology with classical human leukocyte antigen (HLA) molecules, but they do not bind beta-2 microglobulin and peptides.
Abbreviations ACAN: Aggrecan ASC: Adipose tissue-derived stem cells B2M: Beta-2 microglobulin CE: Cartilage explant COL10A1: Collagen type X, alpha 1 COL1A1: Collagen type I, alpha 1 COL2A1: Collagen type II, alpha 1 ECM: Extracellular matrix HAPLN1: Hyaluronan and proteoglycan link protein 1 IL-: Interleukins IM: Incomplete chondrocyte medium MIA: Melanoma inhibitory activity MMP-: Matrix metalloproteinase- (1, 2, 3, 9, and 13) MSC: Mesenchymal stem cells PP: Platelet growth factor-enriched plasma RPS9: 40S ribosomal protein S9 SOX9: Transcription factor SOX-9 TGF [beta]1: Transforming growth factor [beta]1 TSP-1: Thrombospondin-1 TIMP-: Tissue inhibitors of metalloproteinase (1, 2, and 3) 2D: Two-dimensional space 3D: Three-dimensional space VCAM-1: Vascular cell adhesion molecule 1.
A survey of 100 studies on carps in which qPCR was employed showed beta-actin (ACTB) as the most common housekeeping gene (n=32), followed by glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (n=18), 18S ribosomal RNA (18S rRNA) (n=11), elongation factor 1 alpha (EF-1a) (n=8), beta-2 microglobulin (B2M) (n=2), 40S ribosomal protein (40S) (n=1), and other/unlisted (n=28) housekeeping genes.
Mean corrected serum calcium was 10.37 mg/dL with 10 (23%) cases having raised serum calcium >11 mg/dL; 29 (66%) had hypoalbuminemia; 26 (59%) had serum globulin >3.5 to 5.5 and 17 (39%) had >5.5 gm/dL; 11 (25%) had serum beta-2 microglobulin level <3.5 mg/L, 16 (36%) from 3.6 to 5.5 mg/L and 17 (39%) had >5.5 mg/L.
Genetic variability in exon 2 of Beta-2 Microglobulin (B2M) gene in buffaloes and its association with colostral IgG concentration in National symposium on "Policy Planning for Livelihood Security through Domestic Animal Biodiversity" on 11-12 Feb, 2016.