ADRB2

(redirected from Beta-2 adrenoreceptor)

ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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Genetic association between common beta-2 adrenoreceptor polymorphism and asthma severity in school-age children.
That observation, adds Bond, was an indication that blocking the receptor, scientifically known as beta-2 adrenoreceptor, might be a safer and more effective strategy for long-term asthma management than stimulating it.
Genetic variations in drug metabolizing enzymes can lead to the excessive build-up of a drug with a narrow therapeutic index (e.g., thiopurine methyl-transferase and 6-mercaptopurine), or the lack of a therapeutic effect where metabolic activation is required (e.g., cytochrome P450 2D6 and codeine), Likewise, studies have shown that variations in target receptors can lead to a lack of beneficial effects of a drug, for example by increased desensitization (e.g., beta-2 adrenoreceptor and albuterol).