beta-lactamase

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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.
References in periodicals archive ?
Detection of extended spectrum beta lactamases in members of the family Enterobacteriaceae: comparision of the MAST DD test, the double disc and Etest ESBL.
This prospective study was set out to determine the prevalence of Amp C beta lactamases in urinary isolates of Escherichia coli (E.coli), and to evaluate the sensitivity, specificity and over all efficiency of a variety of phenotypic methods based on simple techniques for the detection of Amp C beta lactamases in these isolates.
Frequency of extended spectrum beta lactamase producing gram negative bacilli among clinical isolates.
Phenotypic characteristics of clinical isolates of Klebsiella pneumoniae and evaluation of available techniques for detection of extended spectrum beta lactamases. Indian J Med Res.
Survey beta lactamase production and resistance pattern into beta lactame antibiotics in Bacillus cereus strain isolated from staff hands and hospital environment in Iran.
The present study was conducted in Microbiology Laboratory of Pathology Department, Post Graduate Medical Institute, Lahore to determine frequency of ESBLs and Amp C beta lactamase producing Escherichia coli and Klebsiella pneumoniae isolated from neonatal sepsis in a tertiary care hospital Lahore.
Beta lactams are for example broken down by beta lactamases. There is a whole host of beta lactamases, and new ones seem to be discovered every day.
For amplification of beta lactamases we used two sets of primers for TEM and SHV genes.
Detection of Amp-C beta lactamase producing bacteria is essential in order to establish adequate antibiotic therapy and to achieve encouraging clinical outcomes.