beta-lactamase

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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

β-lactamase

/β-lac·ta·mase/ (lak´tah-mās) any of a group of enzymes, produced by almost all gram-negative bacteria, that hydrolyze the β-lactam ring of penicillins and cephalosporins, destroying their antibiotic activity. Individual enzymes may be called penicillinases or cephalosporinases based on their specificities.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

beta-lactamase

[-lak′təmāz]
Etymology: lactam, a cyclic amide, ase, enzyme
a bacterial enzyme that catalyzes the hydrolysis of the beta-lactam ring of some penicillins and cephalosporins, producing penicilloic acid and rendering the antibiotic ineffective. Also called cephalosporinase, penicillinase.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

β-lactamase

either of two enzymes: β-lactamase I is penicillinase; β-lactamase II is cephalosporinase.
References in periodicals archive ?
Comparison of Various Methods for the Detection of Extended Spectrum Beta Lactamase in Klebsiella Pneumoniae Isolated from Neonatal Intensive Care Unit, Ahmedabad.
Frequency and sensitivity pattern of extended spectrum beta lactamase producing isolates in a tertiary care hospital laboratory of Pakistan.
2011 Frequency of Beta Lactamase Enzyme in Isolated Pathogen Bacteria from Hospital In Vivo and In-Vitro Condition.
Frequency of extended spectrum beta lactamase producing Enterobacteriaceae among urinary pathogen isolates Journal of the College of Physicians and Surgeons Pakistan.
Although more attention has been focussed on beta lactamases than on other enzymes that destroy antibiotics, there are many such enzymes that break down aminoglycosides, chloramphenicol, and so on [5,6].
Evolution and spread of SHV extended-spectrum beta lactamases in gram-negative bacteria.
The production of beta lactamase by bacteria is one of the more common mechanisms that can cause certain widely used antibiotics to be ineffective in treating infections," stated Dr.
Extended spectrum beta lactamases (ESBLs) are plasmid mediated enzymes that confer resistance to oxyimino-[beta]-lactam antibiotics (1).
A study on infections caused by Metallo Beta Lactamase Producing Gram negative bacteria in Intensive care unit patients.