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An enzyme that hydrolyzes the β-galactoside linkage in lactose-producing glucose and galactose; also hydrolyzes the chromogenic substrate IPTG (isopropylthiogalactoside) and thus is used as an indicator of fused genes and gene expression.
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A gene on chromosome 3p21.33 that encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyses the terminal beta-galactose from gangliosides and other glycoconjugates.

Molecular biology
GLB1 mutations cause GM1-gangliosidosis and mucopolysaccharidosis IV (Morquio B syndrome).
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References in periodicals archive ?
The different biochemical tests are listed in Table 3: Beta galactosidase, arginine hydrolase, lysine decarboxylase, ornithine decarboxylase test were all negative for all strains.
Lysosomal enzyme testing showed galactocerebroside beta galactosidase or galactocerebrosidase (GALC) level which was almost undetectable and definitely much below the 99th percentile for age and sex confirming the diagnosis of Krabbe disease.
On determining the activity of this group of enzyme, they found that Beta galactosidase, G N acetyl galactosaminidase and [beta] -N acetyl glucosaminidase were the most active.