(NASDAQ: OPHT) has converted its option and entered into an exclusive global license agreement with the University of Pennsylvania for rights to develop and commercialise novel adeno-associated virus gene therapy product candidates for the treatment of Best vitelliform macular dystrophy, also known as Best disease
and other bestrophinopathies, which are diseases related to mutations to the BEST1 gene, the company said.
Ophthotech has entered into an exclusive option agreement with the University of Pennsylvania and the University of Florida Research Foundation for rights to negotiate to acquire an exclusive global license to develop and commercialize novel adeno-associated virus gene therapy product candidates for the treatment of Best vitelliform macular dystrophy, also known as Best disease
. Best disease
is an orphan inherited degenerative retinal disease caused by mutations in the BEST1 gene.
Frank, "Localization of multifocal electroretinogram abnormalities to the lesion site: findings in a family with Best disease
," Archives of Ophthalmology, vol.
Conclusion: Finding harmless and ecological alternatives to chemical control is an urgent need to face increasing demand for safe, sustainable and effective management plan to white rot of beans counting on biocontrol agents, and other best disease
The managements held with herbicides present a bigger disease incidence on the majority of different pruning seasons done on the three harvests, 2005/2006 to 2007/2008, its AUDPC averagens were, respectively, 185; 302 and 298 (Table 2); and the smaller averages were verified on the OR system with a complete BCLD management, which reduced significantly the disease incidence, 56, 99 and 54, and the same trend were noted in the phenological development of the plant, always showing the best disease
supressor in the different states of the plant's growth (Tables 2 and 5).
"This would provide the very best disease
prevention and remission," said Ferguson.
The best disease
controlling method for organic makers is to avoid diseases in the first place by choosing wheat varieties with good resistance letters.
A 12-hour appointment at Massachusetts Eye and Ear Infirmary in April confirmed the diagnosis of Best disease
, a genetic condition that usually affects the macula, the part of the retina at the back of the eye.
"Ultimately, we hope the model will help us craft treatments to slow or reverse the course of Best disease
First, keep in mind that pathogens mainly affect individuals with a weakened immune system, so healthy food, fresh water, the right amount of exercise, and low stress is the best disease
NAMRU-2 is one of the world's best disease
surveillance facilities, providing health officials worldwide with vital, transparent information.