bergamottin


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bergamottin

(bĕr-ga-mot'in),
One of a group of chemicals found in grapefruit juice (collectively called furanocoumarins), which inhibit CYP450 3A4.
See also: furanocoumarin.
Farlex Partner Medical Dictionary © Farlex 2012

bergamottin

A natural furanocoumarin found in oil of bergamot, grapefruit juice as well as other citrus fruits. Bergamottin and its related metabolites are of pharmacological interest because they inhibit certain cytochrome P450 enzymes, especially CYP3A4, which metabolises an array of drugs from antihistamines to antihypertensives, explaining why certain drugs have greater bioavailability in people who eat a large amount of grapefruit.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The same authors identified bergamottin as one of the best candidates for the treatment of H.
For example, bergamottin, imperatorin, and isopimpinellin inhibited human CYP450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation [8].
It remains to be established if there are any interactions with statins given that bergamot is a source of bergamottin which is believed to be responsible for the grapefruit juice effects on the metabolism of some drugs, including statins (Li et al.
The compounds exerting this action are thought to be either the flavanoids such as naringin and naringinen (17,18,19,20) or the furanocoumarins such as bergamottin and its derivatives (21,22,23,24), but there is no clear consensus.
Drugs associated with moderate (50%-80%) inhibition of 17P were fluconazole (Diflucan), itraconazole (Sporanox), diltiazem, esomeprazole (Nexium), tacrolimus, and bergamottin. Those with weak (30%-50%) inhibitory effects included fluticas-one, voriconazole (Vfend), nifedipine, erythromycin, sertraline (Zoloft), haloperidol (Haldol), and trazodone, and those with negligible (less than 20%) inhibitory effects included midazolam (Versed), quetiapine (Seroquel), venlafaxine (Effexor), citalopram (Celexa), clarithromycin (Biaxin), metronidazole (Flagyl), cyclosporine, sirolimus (Rapamune), and ondansetron (Zofran), said Dr.
A possibility is bergamottin, which is a potent inhibitor of CYP3A4 in vitro and was concentrated in the particulate fraction in the experiments of Bailey et al.
This group includes bergamottin, dihydroxybergamottin (DHB), and a variety of related dimers.
Now, researchers at the University of Michigan and Parke-Davis Pharmaceutical Research, both in Ann Arbor, have identified a compound in grapefruit juice called bergamottin that could be responsible for the effect.
Dreyer and Huey (1973) reported some coumarins like bergamottin, psoralen, marmin, severine, and geiparvarin [37].
Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.