Although the benzoquinones are capable of forming multi-S-substituted adducts and crosslinks, our assay only detected mono-S-substituted adducts.
The effects of cigarette smoking were much more pronounced for adducts of the benzoquinones in both low (< 1 ppm: p = 0.
2002a, 2002b), then our results indicate that the saturable effects are greater for metabolism to the benzoquinones than for metabolism to BO (Figure 1).
Additional work should be conducted to determine why the blood-collection medium would have such a large effect upon levels of albumin adducts of the benzoquinones.
Adducts of the benzoquinones decreased with age at about 0.
KEY WORDS: albumin adduct, benzene oxide, benzoquinone, nonlinear, variation.
Measurement of adducts of benzoquinone with hemoglobin and albumin.
By the general procedure, oxidative cyclisation of the benzoquinone 1A gave the TPDO 1B.
By employing the general procedure, oxidative cyclisation of the benzoquinone 3A gave the TPDO 3B.
Azo containing benzoquinone intermediate failed to give the expected triphenodioxazine compound containing both the TPDO and azo groups; rather it gave free diaminotriphenodioxazine compound as confirmed from its spectroscopic data.