verteporfin

(redirected from Benzoporphyrin)

verteporfin

 [ver″tĕ-por´fin]
a photosensitizing agent that accumulates preferentially in neovasculature, including that in the choroid, such as occurs in age-related macular degeneration, ocular histoplasmosis, or pathologic myopia; the agent is then activated by light of a specific wavelength in the presence of oxygen, and causes local damage to the neovascular endothelium followed by vessel occlusion; it is administered intravenously prior to irradiation of the lesion with light from a compatible laser.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ver·te·por·fin

(vĕr-tē-pōr'fin),
Photosensitizer agent used in photodynamic therapy to treat choroidal neovascularization secondary to age related macular degeneration.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
The photosensitizer drugs segment is further categorized into Hematoporphyrin derivative (HpD), Aminolevulinic acid (ALA), Benzoporphyrin derivative (BPD), Texaphyrins, Chlorins and Dyes.
Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-delivered benzoporphyrin. Arch Ophthalmol 1995;113:810-8.
Some of the exogenous chemical sources of ROS include the xanthine/xanthine oxidase system, which produces [O.sup.-]; the Fenton reagent, which generates [HO.sup.-]; and photosensitizers such as rose bengal and benzoporphyrin derivatives, which produce [sup.1][O.sub.2] upon photosensitization [5,6].
Second-generation photosensitizers include 5-aminolevulinic acid (ALA), benzoporphyrin derivative (BPD), lutetium texaphyrin, temoporfin (mTHPC), tinethyletiopurpurin(SnET2), and talaporfin sodium (LS11).
Verteporfin (benzoporphyrin derivative monoacid ring A) is a derivative of PpIX that has been approved for clinical use.
Four photosensitizing drugs, Photofring, Texas Red, a benzoporphyrin derivative monoacid (BPD), and lutetium texaphyrin (LuTex) were tested to see if they were substrates of the MDR-1 multidrug resistor pump, or if they could be used in PDT.
Quadra Logic is today testing an even stronger free radical-releasing drug called benzoporphyrin derivative, or BPD, which is also activated by light.