benzodiazepine receptor

benzodiazepine receptor

Any of a number of different receptors for benzodiazepine identified in the brain. BZ-1 receptors may affect neural pathways involved in normal sleep patterns, while BZ-2 receptors are involved in memory and motor functions.
References in periodicals archive ?
However, the benzodiazepine receptor agonists such as zaleplon, Zolpidem, and eszopiclone, while lacking evidence in the pediatric population, may be worthwhile considerations as their varying half-lives allow for specificity in treating sleep-onset vs.
Patients met Beers CNS polypharmacy criteria if three or more of the following medications were initiated or continued: antipsychotics, benzodiazepines, nonbenzodiazepine benzodiazepine receptor agonists, tricyclic antidepressants, selective serotonin reuptake inhibitors, and opioids.
Charney, "Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder," American Journal of Psychiatry, vol.
Vomero et al., "Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem," Journal of Medicinal Chemistry, vol.
Guilarte et al., "Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function," Trends in Pharmacological Sciences, vol.
All FDA-approved benzodiazepine receptor agonists work on GABAA receptors; therefore, the difference among them is half-life.
Of special interest is Rozerem is not expected to exhibit rebound insomnia, memory impairment, respiratory depression, drug abuse, dependence, and withdrawal as by some of the benzodiazepine receptor agonists.
Therefore, we used a classic benzodiazepine drug association protocol and a [GABA.sub.A] benzodiazepine receptor site antagonist, flumazenil, for CNS depression reversal.
The 18 kDa translocator protein [1] (TSPO; previously-known as the peripheral benzodiazepine receptor, PBR) has been extensively studied for its intricate biological functions.
angustifolia has been found to contain flavonoid components and some flavones, such as chrysin, (5, 7-dihydroxyflavone) which have a partial agonistic effect on benzodiazepine receptors. Central benzodiazepine receptor (BDZ-R) agonists have been known to induce multiple effects including anxiolytic, myorelaxant, anticovulsant, hypnotic and amnestic effects (44-46).