BCR

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BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
References in periodicals archive ?
Benefit Cost ratio of newly launched passenger trains was also discussed wherein the minister informed that out of 10 new trains, six are running under loss but the overall result is positive.
Table 6: Total cost, net return and benefit cost ratio as influenced by sowing of wheat with different no-till techniques in combine harvested rice field with various stubble heights
The computed values of cost of energy (COE), payback period, net present value (NPV) and benefit cost ratio (BCR) are based on previously listed assumptions Table 4.
Combined application of the organic and inorganic fertilizers may result in higher benefit cost ratio than their sole application.
For instance, the Benefit Cost Ratio to rail users in the east is 5.6 compared to just 2.6 for the Birmingham to Manchester western route and bringing businesses closer together will result in productivity benefits of PS2.6bn in the east, some 20% higher than in the west.
| Benefit Cost Ratio: PS2.70 benefits per PS1 invested.
The net benefit and benefit cost ratio were then calculated to determine the profitability of each practice.
The Australian Transport Council (ATC) have identified that the benefit cost ratio (BCR), the net present value (NPV), and first-year rate of return (FYRR) decision criteria are appropriate inputs to project prioritization, mutual exclusive project selection, and optimal timing, respectively.
Campaigners insist the HS2 business case has fallen apart in recent weeks after: * The government's crucial benefit cost ratio (BCR) was revised down for a fourth time.
The benefit cost ratio (BCR) of organic and inorganic rice crop was calculated in district Sheikhupura on per acre basis.
Broadly speaking, ROI is reflected by numbers: these include the benefit cost ratio (B/C; a number greater than one implies that the program is justified on both internal efficiency and external effectiveness grounds); the net present value (NPV; a number greater than zero implies that building the program today is justified instead of waiting for the future); and the internal rate of return (IRR; when the rate of return obtained from program implementation exceeds the market interest rate; this is the measure used to determine returns from financial investing).
This shows that benefit cost ratio of 1.14 reduced significantly when external cost was added in the total cost.