IgD multiple myeloma is characterized by a small or absent M-protein band in electrophoresis, a Lambda (A) light chain bias, and Bence-Jones proteinuria, which occurred in at least 90% of patients (7).
Furthermore, Lolin et al (1994) suggested that immunofix with IgD and IgE antisera should routinely be performed for all patients with a suspected Bence-Jones proteinuria myeloma, irrespective of whether a suspicious band was detected on serum protein electrophoresis or after immunofixation with light chains (9).
[3,11,12,14] Tubular dysfunction has been reported in patients with myeloma and Bence-Jones proteinuria
. In our study, 8.3% patients with multiple myeloma had renal glycosuria.
The vast majority of these patients excrete these monoclonal light chains in the urine; this has traditionally been termed Bence-Jones proteinuria
. (11,12) The College of American Pathologists' guidelines for detecting and quantifying BJP are based on a 24-hour urine specimen.
Common laboratory findings included anemia, slightly elevated calcium levels, lytic bone lesions, and serum monoclonal gammopathy or Bence-Jones proteinuria
Electrophoretic study of the physico-chemical characteristics of Bence-Jones proteinuria
and its association with kidney damage.
The optimum urine collections and monitoring of Bence-Jones proteinuria
. Am J Clin Pathol 1990;93:689-93.