light chain disease

(redirected from Bence-Jones myeloma)

light chain disease

A nephropathy which presents with nephrotic range proteinuria and rapidly progressive renal failure due to deposition of electron-dense material within tubular and glomerular basement membranes.

Clinical findings
Nephrotic syndrome, heart failure, arrhythmias, liver disease, anorexia, nausea, weight loss, anaemia, increased creatinine, and neurologic disease; similar clinical findings occur in heavy chain deposition.
References in periodicals archive ?
Light chain deposition disease or Bence-Jones myeloma is a progressive disease characterized by plasma cell proliferation in the bone marrow and overproduction of the light chain portion of immunoglobulins (Bence Jones proteins) in plasma and in urine [2].
Light chain deposition disease or Bence-Jones myeloma is a progressive disease characterized by proliferation of plasma cells in the bone marrow and overproduction of light chain immunoglobulins (Bence-Jones proteins) in plasma and urine [2].
After reviewing all these data, we obtained the following results: there have been 12 cases with cancer (including the case reported here), namely, 1 renal adenocarcinoma, 2 prostate adenocarcinomas, 4 multiple myelomas, 1 Bence-Jones myeloma, and 3 non-Hodgkin lymphoma (1 with squamous cell carcinoma of the lung and other with pancreatic ductal adenocarcinoma).