Even in this 11% of cases (of intact monoclonal immunoglobulins), an accompanying small amount of Bence Jones proteinuria cannot be excluded because the detection rates with the F [kappa] and F [lambda] reagents were much lower than those with the F+B light chain reagents.
Reactivity of Bence Jones proteinuria assay antisera in the urine immunofixation test.
Although the primary focus of MDI-LabLink is the quantification of glomerular or tubular damage, it suggested immunofixation in most cases of Bence Jones proteinuria
(7 of 10 cases of the study group) seen on the gel by routinely calculating the difference between total protein content and the sum of all measured specific proteins (19).
The association of Bence Jones proteinuria with low total-immunoglobulin concentrations was tested using the baseline-integrated AUC between haptoglobin and SS1 minus the C3 and transferrin areas (see above) normalized with respect to the AUC for SS1.
The algorithms cannot replace immunofixation for the determination of immunoglobulin class or urine analysis for the identification and quantification of Bence Jones proteinuria. Algorithms function well as an initial screening of polyclonal immunoglobulin concentrations, but they cannot differentiate between IgG and IgM.
A product of improved methodology that may complicate recognition of Bence Jones proteinuria
. Arch Pathol Lab Med 1993;117:707-10.
Urinary investigations for patients with multiple myeloma (MM)3 include electrophoretic protein screening (evaluation of renal function, detection of an abnormal protein fraction) followed by immunofixation (IFE) for identification of a monoclonal component [intact immunoglobulin or monoclonal free light chains: Bence Jones proteinuria