Bence Jones protein


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Bence Jones protein

[bens]
Etymology: Henry Bence Jones, English physician, 1814-1873
a protein found almost exclusively in the urine of patients with multiple myeloma. The protein constitutes the light chain component of myeloma globulin; it coagulates at temperatures of 45° to 55° C and redissolves completely or partially on boiling. See also multiple myeloma, protein.

Bence Jones protein

An abnormal 22–24-kD monoclonal of light-chain—usually kappa, less commonly, lambda—immunoglobulin derived from the clonal expansion(s) of plasma cells, which is found in the urine of 50–80% of patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Bence-Jones protein is small enough to be excreted by the kidney.

Specimen
24-hour urine.
 
Comments
False-positive results can occur in connective tissue disease, renal insufficiency and in other malignancies. Immunofixation electrophoresis—or more recently, serum-free light-chain assay—is the preferred method for detecting BJPs. The heat detection method—Bence Jones reaction (see there)—has fallen into disuse.

Bence Jones protein

An abnormal dimer of light-chain Ig derived from the clonal expansion of plasma cells, found in the urine of 50-80% of Pts with myeloma and Waldenstrom's macroglobulinemia; these proteins are small enough to be excreted by the kidney

Bence Jones protein

A MONOCLONAL immunoglobulin formed in excess by B lymphocytes and found in the serum and urine in cases of MYELOMATOSIS. (Henry Bence Jones, 1818–1873, English physician).

Bence Jones protein

Small protein, composed of a light chain of immunoglobulin, made by plasma cells.

Bence Jones protein,

n.pr protein commonly found in patients suffering from multiple myeloma.

Bence Jones protein,

Bence Jones protein

immunoglobulin light chain dimers found in the serum and urine of patients and animals with gammopathies, usually myelomas.
References in periodicals archive ?
The present case suggests that in patients with [Beta]-migrating Bence Jones proteins and evidence of renal tubular dysfunction, a confirmatory repeat UIFE may be warranted when serial Bence Jones protein levels measured using UPEP with densitometric scanning appear inconsistent with clinical findings (ie, do not decrease with other signs of clinical improvement) or increase unexpectedly.
As a control, we used the urine from a myeloma patient with [kappa] Bence Jones protein without cryo formation.
Bence Jones proteins and light chains of immunoglobulins.
Correlation of serum immunoglobulin free light chain quantitation with urine Bence Jones protein in light chain myeloma [Technical Brief].
In some cases myeloma cells secrete immunoglobulins that contain only the light chains, these are secreted in the urine and are known as Bence Jones proteins (2).
Pathobiology of cast nephropathy from human Bence Jones proteins.
Further investigations revealed that Bence Jones proteins were absent from the urine, and an analysis of serum immunoglobulins found no monoclonal paraproteins.