Benadryl


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Benadryl

 [ben´ah-dril]
trademark for preparations of diphenhydramine hydrochloride, an antihistamine.

diphenhydramine hydrochloride

Aler-Cap, Aler-Dryl, Allerdryl (CA), AllerMax, Altaryl, Anti-Hist, Banophen, Benadryl, Benadryl Allergy, Benadryl Child Chesty Cough (UK), Benadryl Children's Allergy Fastmelt, Benadryl Dye-Free Allergy, Benadryl Itch Relief, Compoz Nighttime Sleep Aid, Dermamycin, Diphen, Diphenhist, Dytan, Genahist, Histapryn, Histergan (UK), Hydramine, Mandalyn Paedetriac (UK), Nightcalm, Nytol, PMS-Diphenhydramine (CA), Siladryl, Simply Sleep, Sleepeaze (UK), Sleepettes D, Sleepinal, Sominex, Theraflu Thin Strips Multisymptom, Triaminic Thin Strips Children's Cough and Runny Nose, Twilite, Unisom Maximum Strength SleepGels

Pharmacologic class: Ethanolamine derivative, nonselective histamine1-receptor antagonist

Therapeutic class: Antihistamine, antitussive, antiemetic, antivertigo agent, antidyskinetic

Pregnancy risk category B

Action

Interferes with histamine effects at histamine1-receptor sites; prevents but doesn't reverse histamine-mediated response. Also possesses CNS depressant and anticholinergic properties.

Availability

Capsules: 25 mg, 50 mg

Elixir: 12.5 mg/5 ml

Injection: 10 mg/ml, 50 mg/ml

Strips (orally disintegrating): 12.5 mg, 25 mg

Syrup: 12.5 mg/5 ml

Tablets: 25 mg, 50 mg

Tablets (chewable): 12.5 mg, 25 mg

Tablets (orally disintegrating): 12.5 mg

Indications and dosages

Allergy symptoms caused by histamine release (including anaphylaxis, seasonal and perennial allergic rhinitis, and allergic dermatoses); nausea; vertigo

Adults and children over age 12: 25 to 50 mg P.O. q 4 to 6 hours, or 10 to 50 mg I.V. or I.M. q 2 to 3 hours p.r.n. (Some patients may need up to 100 mg.) Don't exceed 400 mg/day.

Children ages 6 to 12: 12.5 to 25 mg P.O. q 4 to 6 hours, or 1.25 mg/kg (37.5 mg/m2) I.M. or I.V. q.i.d. Don't exceed 150 mg/day.

Children ages 2 to 5: 6.25 mg P.O. q 4 to 6 hours. Don't exceed 37.5 mg/day.

Cough

Adults: 25 mg P.O. q 4 hours p.r.n. Don't exceed 150 mg/day.

Children ages 6 to 12: 12.5 mg P.O. q 4 hours. Don't exceed 75 mg/day.

Children ages 2 to 5: 6.25 mg P.O. q 4 hours. Don't exceed 37.5 mg/24 hours.

Dyskinesia; Parkinson's disease

Adults: Initially, 25 mg P.O. t.i.d.; may be increased to a maximum of 50 mg q.i.d.

Mild nighttime sedation

Adults: 50 mg P.O. 20 to 30 minutes before bedtime

Dosage adjustment

• Elderly patients

Off-label uses

• Drug-induced extrapyramidal reactions

Contraindications

• Hypersensitivity to drug

• Alcohol intolerance

• Acute asthma attacks

• MAO inhibitor use within past 14 days

• Breastfeeding

• Neonates, premature infants

Precautions

Use cautiously in:

• severe hepatic disease, angle-closure glaucoma, seizure disorders, prostatic hypertrophy, cardiovascular disease, hyperthyroidism

• elderly patients

• pregnant patients (safety not established)

• children younger than age 2 (safety not established).

Administration

• For motion sickness, administer 30 minutes before activity.

• For I.V. use, check compatibility before mixing with other drugs.

• Inject I.M. dose deep into large muscle mass; rotate sites.

• Discontinue drug 4 days before allergy skin testing to avoid misleading results.

Don't give within 14 days of MAO inhibitors.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (especially in children)

CV: hypotension, palpitations, tachycardia

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency or retention

Skin: photosensitivity

Other: decreased appetite, pain at I.M. injection site

Interactions

Drug-drug. Antihistamines, opioids, sedative-hypnotics: additive CNS depression

Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Drug-diagnostic tests. Skin allergy tests: false-negative results

Hemoglobin, platelets: decreased values

Drug-herbs. Angel's trumpet, jimson weed, scopolia: increased anticholinergic effects

Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Monitor cardiovascular status, especially in patients with cardiovascular disease.

• Supervise patient during ambulation. Use side rails as necessary.

Patient teaching

• Advise patient to avoid alcohol and other depressants such as sedatives while taking drug.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

Benadryl

(bĕn′ə-drĭl)
A trademark for the drug diphenhydramine hydrochloride.

Benadryl

A proprietary antihistamine developed in the mid-1940s which, like other older sedating agents, has been associated with fatal RTAs/MVAs.
 
Adverse effects Drowsiness, heartburn, dizziness.

Benadryl®

Diphenhydramine Allergy medicine An antihistamine which, like other older sedating agents, has been associated with fatal MVAs. See Antihistamine.

Benadryl

A brand name for DIPHENHYDRAMINE.
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outside India (it is popular among teens who drink it to get high), a section of the Air India cabin crew started smuggling bottles of Benadryl to London and elsewhere, our sources in the airline said.
Though both dogs had experienced a number of stings, after the Benadryl that my sister procured had been administered, they recovered quickly from the physical effects of the bees' attack.
LaLaurie gives Marie a drink, which has tablets of Benadryl. When Marie looks drugged, LaLaurie puts a knife in her heart.
Photographs taken by police at the couple's apartment showed a medicine cup on the bathroom sink with a residue in it similar in color to Benadryl, according to Ms.
Consequently, the domestic market is now-a days facing a shortage of some medicines like Thyroxine Tablet, Vancocin injection, Cardarone Tablet, Inderal Tablet, Benadryl syrup, Xanax Tablet, Lexotanil Tablet, Ativan Tablet, Betnesol N drops, Betnesol Tablet, Polyfax eye ointment, Hydryllin DM syrup and Arinac Tablet, he further added.
Gautam Suri, General Marketing Manager, Consumer Division, Johnson & Johnson Ltd, states, "With the launch of Benadryl(R) Congestion Relief, Johnson & Johnson is taking its first step towards building a cough expert equity under 'Benadryl'.
William Weldon, who was CEO of Johnson & Johnson until April of this year, presided over a series of recalls of "Tylenol, Benadryl, Motrin and Zyrtec as a result of such problems as metal shavings found in medicines, incorrect levels of an active ingredient and bad odors," according to the Wall Street Journal.
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Ph.D., on the grounds that he was not qualified to offer expert medical testimony: 2.) granted Defendants' motion in limine to exclude evidence that Campbell suffered negligent infliction of emotional distress, on the grounds that no such claim had been properly pleaded; and 3) granted the Defendants' motion in limine to exclude evidence of breaches of the standard of care, other than the overdose of Benadryl, that were not presented to the medical review panel.
I'd already figured that one out, but not soon enough.) The doctor treated the problem in the standard way for a severe allergic reaction, injections of epinephrine, prednisone, and Benadryl. He told me that I'd have to figure out for myself what had caused the swelling, and gave me prescriptions for an Epi-pen and prednisone.