Becker muscular dystrophy


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Related to Becker muscular dystrophy: distal muscular dystrophy

Beck·er mus·cu·lar dys·tro·phy

, Becker-type tardive muscular dystrophy (bek'ĕr),
a hereditary muscle disorder of late onset, usually in the second or third decade, affecting the proximal muscles with characteristic pseudohypertrophy of the calves; clinical features similar to Duchenne muscular dystrophy but much milder and not a genetic lethal; X-linked recessive inheritance, with both Becker and Duchenne dystrophies caused by mutation in the dystrophin gene on Xp. Compare: Duchenne dystrophy.

Becker muscular dystrophy

(bĕk′ər)
n.
A form of muscular dystrophy that begins in late childhood or adolescence, almost exclusively affects males, and is characterized by progressive weakening of the muscles that is similar to but less severe than in Duchenne muscular dystrophy. It is caused by a recessive genetic mutation on the X chromosome that results in insufficiency or abnormality of the protein dystrophin in muscle cells.

Beck·er mus·cu·lar dys·tro·phy

,Becker-type tardive musculardystrophy (bek'er mŭs'kyū-lăr dis'trŏ-fē, -tīp tahr'div)
A hereditary muscle disorder of late onset, usually in the second or third decade, affecting the proximal muscles with characteristic pseudohypertrophy of the calves; clinical features similar to Duchenne muscular dystrophy but much milder and not a genetic lethal; X-linked recessive inheritance, with both Becker and Duchenne dystrophies caused by mutation in the dystrophin gene on Xp.
Compare: Duchenne dystrophy

Becker muscular dystrophy (BMD)

A type of muscular dystrophy that affects older boys and men, and usually follows a milder course than DMD.
Mentioned in: Muscular Dystrophy

Becker,

Peter Emil, German geneticist, 1908–.
Becker muscular dystrophy - a muscular dystrophy that has many of the clinical features of Duchenne muscular dystrophy. Synonym(s): adult pseudohypertrophic muscular dystrophy; Becker-type tardive muscular dystrophy
Becker-type tardive muscular dystrophy - Synonym(s): Becker muscular dystrophy
References in periodicals archive ?
Differentiation of Duchenne and Becker muscular dystrophy phenotypes with amino - and carboxy - terminal antisera specific for dystrophin.
DNA-based techniques for detection of carriers of duchenne and becker muscular dystrophy. Muscular Dystrophy 2001;43:111-35.
* The report provides a snapshot of the global therapeutic landscape of Becker Muscular Dystrophy
Novel mutation in spectrin-like repeat 1 of dystrophin central domain causes protein misfolding and mild Becker muscular dystrophy. J Biol Chem 2012; 287(22):18153-18162.DOI: 10.1074/jbc.
Molecular deletion patterns in Duchenne and Becker muscular dystrophy patients from KwaZulu Natal.
Becker muscular dystrophy results from a genetic defect that reduces the amount of a protein called dystrophin in the membrane of muscle cells.
The importance of establishing this diagnosis versus similar and more-common Becker muscular dystrophy is that it has significant treatment implications.
Pattern of deletions of the dystrophin gene in Mexican Duchenne/ Becker muscular dystrophy patients: the use of new designed primers for the analysis of the major deletion "hot spot" region.
Cardiac involvement in Duchenne and Becker muscular dystrophy. World J Cardiol 2015;7:410-4.
[USPRwire, Mon Apr 27 2015] Global Markets Direct's, 'Becker Muscular Dystrophy - Pipeline Review, H1 2015', provides an overview of the Becker Muscular Dystrophy's therapeutic pipeline.
2 December 2010 - US biopharmaceutical company PTC Therapeutics Inc said yesterday that data published in the December issue of the medical journal Muscle and Nerve confirm the utility of six-minute walk distance (6MWD) as a clinically meaningful endpoint in dystrophinopathy, a disease continuum comprising Duchenne and Becker muscular dystrophy (DBMD).
Genes frequently involved in complex GKD include DMD, variations in which cause Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), and NR0B1 (DAX1), which is responsible for adrenal hypoplasia congenita (AHC) (2, 3).