BAX

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BAX

BAX
A gene located on chromosome 19q13.3-q13.4, which encodes Bax, which belongs to the BCL2 family of proteins with which it forms a heterodimer, together acting as anti- or pro-apoptosis regulators, depending on whether Bax or Bcl-2 is greater. BAX expression is regulated by p53, the tumour suppressor, and is involved in p53-mediated apoptosis.

Bax
A 21-kD protein encoded by BAX, located on chromosome 19q13.3-q13.4, which has significant homology with Bcl-2, the apoptosis repressor, with which it forms a heterodimer. Overexpression of Bax compared to Bcl-2 signifies apoptosis.
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References in periodicals archive ?
Quantification of ten transcripts-aggrecan (AGG); type II collagen, alpha-1 chain (COL2A1); matrixmetalloproteinase-3 (MMP-3); hyaluronan synthase-1 (HAS-1); hyaluronan synthase-2 (HAS-2); tissue inhibitor of metalloproteinase-1 (TIMP-1); Bcl-2-associated X protein (BAX); B-cell lymphoma-2 (BCL-2); cysteine aspartate-specific protease-3 (CAS-3); and cysteine aspartate-specific protease-9 (CAS-9) (Shanghai BlueGene Biotech, Shanghai, China)--was performed for all samples.
AGG y = -0.016x + 1.188 0.899 0.808 0.000 COL2A1 y = -0.039x + 1.172 0.963 0.928 0.000 MMP-3 y = 0.036x + 0.800 0.953 0.907 0.000 HAS-1 y = -0.027x + 1.334 0.967 0.936 0.000 HAS-2 y = -0.023x + 1.245 0.953 0.908 0.000 TIMP-1 y = -0.029x + 1.226 0.965 0.930 0.000 BAX y = 0.031x + 0.760 0.993 0.986 0.000 BCL-2 y = 0.029x + 1.180 0.846 0.715 0.000 CAS-3 y = 0.025x + 0.625 0.928 0.861 0.000 CAS-9 y = 0.032x + 0.751 0.993 0.985 0.000 AGG:aggrecan; COL2A1: type II collagen, alpha-1 chain; MMP-3: matrix metalloproteinase-3; HAS-1: hyaluronan synthase-1; HAS-2:hyaluronan synthase-2; TIMP-1: tissue inhibitor of metalloproteinase-1; BAX: Bcl-2-associated X protein; BCL-2:B-cell lymphoma-2; CAS-3: cysteine aspartate-specific protease-3; CAS-9: cysteine aspartate-specific protease-9.