bcl-2

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BCL-2

An oncogene that inhibits apoptosis.
Farlex Partner Medical Dictionary © Farlex 2012

Bcl-2

A 25 kDa inner mitochondrial membrane protein which inhibits apoptosis, thus increasing the survival of cells (good or bad). The t(14;18) translocation results in a hybrid bcl-2/immunoglobulin heavy chain transcript consisting of the 5’ half of the bcl-2 mRNA fused to a truncated immunoglobulin heavy chain mRNA.

Normal expression
It is normally expressed by small B lymphocytes of the mantle and marginal zones and by many T cells.

Abnormal expression
Bcl-2 is over expressed in follicular lymphomas with the translocation t(14;18)(q32;q21), detected in 70 to 95% of follicular lymphomas and 20% of diffuse large B cell lymphomas. Expression is greater in grade I than in grade III follicular lymphomas.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

BCL-2

An oncogene that inhibits apoptosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

bcl-2

Proto-ONCOGENEs. This gene is over-expressed in various tumours, especially non-Hodgkin lymphoma, resulting in resistance to APOPTOSIS (programmed cell death) with encouragement of tumour growth. Antisense nucleotide sequences (oligonucleotides) targeted at BCL-2 messenger RNA reduces the expression of BCL-2 and increases apoptosis in these tumours with clinical improvement.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Bcl-2 protein ailesi apoptozisi inhibe eden (Bcl-2, Bcl-xL, Mcl-1, Bcl-w, A1/Bfl1 gibi) veya aktive eden (Bax, Bak, Bad, Bim, Bik, Noxa, Puma, Hrk gibi) birbirleri ile yuksek oranda yapisal homoloji gosteren proteinlerden meydana gelmis bir ailedir.
In some similar manner, Bax protein contents were significantly increased and Bcl-2 protein contents were concomitantly decreased in FA group compared to the control group (P < 0.
However, treatment with 2,4-thiazolidinedione was observed to reverse these effects, reducing Bax and increasing Bcl-2 protein levels significantly.
Zhang et al., "Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Changes of Bax and Bcl-2 Protein Expressions in Response to S-ISL Treatment.
Bcl-2 protein was detected as 26 kDa band and the internal control [beta]-actin as 41 kDa.
The families of Bcl-2 protein and Bax protein were found to be the most important apoptosis protein.
The induction of apoptosis by cathachunine occurred through an ROS-dependent mitochondria-mediated intrinsic pathway rather than an extrinsic pathway, and was regulated by the Bcl-2 protein family.
According to the company, VENCLEXTA is a small molecule inhibitor of the BCL-2 protein. VENCLEXTA has a distinct mechanism of action; it targets BCL-2, a protein central to the survival of CLL cells.