bcl-2

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BCL-2

An oncogene that inhibits apoptosis.

Bcl-2

A 25 kDa inner mitochondrial membrane protein which inhibits apoptosis, thus increasing the survival of cells (good or bad). The t(14;18) translocation results in a hybrid bcl-2/immunoglobulin heavy chain transcript consisting of the 5’ half of the bcl-2 mRNA fused to a truncated immunoglobulin heavy chain mRNA.

Normal expression
It is normally expressed by small B lymphocytes of the mantle and marginal zones and by many T cells.

Abnormal expression
Bcl-2 is over expressed in follicular lymphomas with the translocation t(14;18)(q32;q21), detected in 70 to 95% of follicular lymphomas and 20% of diffuse large B cell lymphomas. Expression is greater in grade I than in grade III follicular lymphomas.

BCL-2

An oncogene that inhibits apoptosis.

bcl-2

Proto-ONCOGENEs. This gene is over-expressed in various tumours, especially non-Hodgkin lymphoma, resulting in resistance to APOPTOSIS (programmed cell death) with encouragement of tumour growth. Antisense nucleotide sequences (oligonucleotides) targeted at BCL-2 messenger RNA reduces the expression of BCL-2 and increases apoptosis in these tumours with clinical improvement.
References in periodicals archive ?
By using GAPDH as the reference gene, the mRNA altitude of Bcl-2 genes was resolved through (DCt) method, through the deduction of average DCt of the sample from the DCt of the control the DDCt values were calculated and were converted to fold difference by raising 2 to the power DDCt (2^DDCt).
In addition, investigators have shown that Bcl-2 gene family is known to modulate the permeability of the mitochondrial membrane and the release of cytochrome C [41].
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.
The study findings potentially could refine this approach so that chemotherapy can be timed more effectively, killing off cancer cells and preventing a relapse when the BCL-2 gene is sufficiently weak.
Involvement of the bcl-2 gene in human follicular lymphoma, Science, 228: 1440-3.
Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: glandular epithelial cell apoptosis is associated with increased expression of bax.
Importantly, the Trinity team also discovered that members of the Bcl-2 gene family could override this process, switching off the self-eating process and leading to survival of cancerous cells.
These results can be explained on the basis of findings of Chattopadhya et al [10], which showed that I/R injury inhibits Bcl-2 gene expression resulting and bind to the "permeability transition pore" of mitochondrial membrane inducing loss of selective ion permeability which results in release into the cytosol intermembrane space contents including cytochrome c and apoptosis-inducing factor (AIF).
HL-60bcl-2 cells, which are derived from a stable transfectant clone of the human bcl-2 gene into the HL-60 leukemia cell line, show 5-fold greater expression of the Bcl-2 protein compared with HL-60neo cells, a control clone transfected with vector alone.
The patient's positive BCL-2 gene findings helped to clinch the diagnosis.