bcl-2

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BCL-2

An oncogene that inhibits apoptosis.
Farlex Partner Medical Dictionary © Farlex 2012

Bcl-2

A 25 kDa inner mitochondrial membrane protein which inhibits apoptosis, thus increasing the survival of cells (good or bad). The t(14;18) translocation results in a hybrid bcl-2/immunoglobulin heavy chain transcript consisting of the 5’ half of the bcl-2 mRNA fused to a truncated immunoglobulin heavy chain mRNA.

Normal expression
It is normally expressed by small B lymphocytes of the mantle and marginal zones and by many T cells.

Abnormal expression
Bcl-2 is over expressed in follicular lymphomas with the translocation t(14;18)(q32;q21), detected in 70 to 95% of follicular lymphomas and 20% of diffuse large B cell lymphomas. Expression is greater in grade I than in grade III follicular lymphomas.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

BCL-2

An oncogene that inhibits apoptosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

bcl-2

Proto-ONCOGENEs. This gene is over-expressed in various tumours, especially non-Hodgkin lymphoma, resulting in resistance to APOPTOSIS (programmed cell death) with encouragement of tumour growth. Antisense nucleotide sequences (oligonucleotides) targeted at BCL-2 messenger RNA reduces the expression of BCL-2 and increases apoptosis in these tumours with clinical improvement.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The results showed a significant increase in p53 mRNA level in TE1, TE8, and TE11 cells while Bcl-2 gene expression decreased simultaneously.
A BCL-2 gene polymorphism (rs2279115) is correlated with the occurrence of leukemia in Iraqi population.
The transcripts of Bax and Bcl-2 genes were detected in day7 blastocyst originating from oocytes matured in different treated groups.
However, an improvement in Bcl-2 gene expression (Group SP-3 d vs Group Con-3 d; Group SP-6 d vs Group Con-6 d; Group SP-9 d vs Group Con-9 d) was noted in the thymus (p<0.05).
Densitometry results for Bax and Bcl-2 genes were compared with corresponding [beta]-actin levels to account for loading differences.
Abdul hamid et al., "Flower extract of Allium atroviolaceum triggered apoptosis, activated caspase-3 and down-regulated antiapoptotic Bcl-2 gene in HeLa cancer cell line," Biomedicine & Pharmacotherapy, vol.
Nunez, G., et al., Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor- deprived hemopoietic cell lines.
BCL-2 gene family and the regulation of programmed cell death.
Bcl-2 gene was elevated 1.13-fold and Bax mRNA level decreased 0.4-fold relative to MCF-7 cells [12]; however, it did not have a significant effect on changing P53 gene expression.
Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma.