bcl-2


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BCL-2

An oncogene that inhibits apoptosis.
Farlex Partner Medical Dictionary © Farlex 2012

Bcl-2

A 25 kDa inner mitochondrial membrane protein which inhibits apoptosis, thus increasing the survival of cells (good or bad). The t(14;18) translocation results in a hybrid bcl-2/immunoglobulin heavy chain transcript consisting of the 5’ half of the bcl-2 mRNA fused to a truncated immunoglobulin heavy chain mRNA.

Normal expression
It is normally expressed by small B lymphocytes of the mantle and marginal zones and by many T cells.

Abnormal expression
Bcl-2 is over expressed in follicular lymphomas with the translocation t(14;18)(q32;q21), detected in 70 to 95% of follicular lymphomas and 20% of diffuse large B cell lymphomas. Expression is greater in grade I than in grade III follicular lymphomas.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

BCL-2

An oncogene that inhibits apoptosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

bcl-2

Proto-ONCOGENEs. This gene is over-expressed in various tumours, especially non-Hodgkin lymphoma, resulting in resistance to APOPTOSIS (programmed cell death) with encouragement of tumour growth. Antisense nucleotide sequences (oligonucleotides) targeted at BCL-2 messenger RNA reduces the expression of BCL-2 and increases apoptosis in these tumours with clinical improvement.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
A BCL-2 gene polymorphism (rs2279115) is correlated with the occurrence of leukemia in Iraqi population.
The BCL-2 protein family: Opposing activities that mediate cell death.
We hypothesize that transformation of CD-NSCs will not occur upon transient Bcl-2 overexpression based on the following rationale.
Establishment of Cells Stably Expressing Bcl-2. Cells stably expressing Bcl-2 were established by transforming MC3T3E1 cells with a Bcl-2 expression vector (pCMV-Bcl-2) and a plasmid with a puromycin-resistance gene (pBabePuro).
In contrast with the PLA group, as the phosphorylation of ERK1/2 was inhibited by PD98059, the expression of proapoptotic protein Bax was decreased and the expression of antiapoptotic protein Bcl-2 was restored (Figure 6(a)).
Bu siniftaki inhibitorler icin kullanilan Bcl-2 inhibitor terimi, hucre yasamini tesvik eden protein ailesi uyelerini baglayan ilaclari kapsamaktadir.
Compared with the CTRL group, the levels of Bcl-2 and Bcl-xl in the LPS group were decreased.
Conclusion: Ferulic acid could significantly descend osteosarcoma cell viability through the promoting apoptosis pathway in which FA activates both caspase-3 and Bax and inactivates Bcl-2.
In addition, several studies on neuroendocrine tumors have reported that bcl-2 or p53 expression might be correlated with malignant behavior [13-17,19, 23-27].
Some important examples of cancer macromolecules are B-cell lymphoma 2 (Bcl-2), vascular endothelial growth factor receptor 2 (VEGFR-2), cyclin-dependent protein kinase 6 (CDK-6), CDK-2, IGF-1R kinase (insulin-like growth factor 1 receptor), and G-Quadruplexes [1].
Feng [11] found that promoting blood circulation compound can improve apoptosis and the expression of regulatory genes, Bcl-2 and Bax.