basophil

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Related to Basophils: Monocytes, Lymphocytes, Eosinophils, Neutrophils

basophil

 [ba´so-fil]
1. any structure, cell, or histologic element staining readily with basic dyes.
2. a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm containing coarse bluish-black granules of variable size; about 1 per cent bring anticoagulants to inflamed tissues. Called also basophilic leukocyte.
3. one of the hormone-producing basophilic cells of the adenohypophysis; types include gonadotrophs and thyrotrophs. Called also beta cell.

ba·so·phil

, basophile (bā'sō-fil, -fīl),
1. A cell with granules that stain specifically with basic dyes.
2. Synonym(s): basophilic
3. A phagocytic leukocyte of the blood characterized by numerous basophilic granules containing heparin, histamine, and leukotrines; except for its segmented nucleus, it is morphologically and physiologically similar to the mast cell although they originate from different stem cells in the bone marrow.
[baso- + G. philēo, to love]

basophil

(bā′sə-fĭl, -zə-) also

basophile

(-fīl′, -fĭl)
n.
A cell, especially a white blood cell, having granules that stain readily with basic dyes.

basophil

A type of granular leukocyte with large, distinctly basophilic/“blue” secondary granules containing heparin, histamine, platelet-activating factor (PAF) and other mediators of the immediate hypersensitivity response, which are released when IgE cross-links to the high-affinity Fc receptors on the cell surface.

basophil

Basophilic granulocyte Hematology A type of granular WBC with large distinctly basophilic/“blue” 2º granules containing heparin, histamine, PAF and other mediators of the immediate hypersensitivity response, which are released when IgE cross-links to the high affinity Fc receptors on the cell surface

ba·so·phil

, basophile (bā'sō-fil, -fīl)
1. A cell with granules that stain specifically with basic dyes.
2. Synonym(s): basophilic.
3. A phagocytic leukocyte of the blood characterized by basophilic granules containing heparin and histamine; except for its segmented nucleus, it is morphologically and physiologically similar to the mast cell, although the two cell types originate from different stem cells in the bone marrow.
[baso- + G. philēo, to love]

basophil

Having an affinity for alkali. The term is used conveniently to refer to the group of blood white cells (leukocytes) whose internal granules take up an alkaline stain. The granules in basophils are mainly histamine and it is the release of this powerful chemical that causes most of the trouble in allergy. Basophils closely resemble tissue MAST CELLS.

Basophil

White blood cell that increases in response to parasitic infections and allergic reactions.

ba·so·phil

, basophile (bā'sō-fil, -fīl)
A phagocytic leukocyte of the blood characterized by numerous basophilic granules containing heparin, histamine, and leukotrines.
[baso- + G. philēo, to love]
References in periodicals archive ?
Measuring leukotrienes from supernatants of stimulated basophils by radio immune-assay as alternative to histamine release was pointed out by MacGlashan Jr.
Bar: 200[micro]m; B: Columnar epithelial cells (Ep) with basophil cytoplasm (*) and nucleus with predominate decondensed chromatin.
The basophil activation test (BAT) was positive to rocuronium, rocuronium plus sugammadex and cisatracurium and negative to succinylcholine.
For basophils it was 100%, while the lowest evidence in the eosinophils has a value of 73.07% as shown in Figures 5(a) and 5(b), respectively, and for lymphocytes a percentage of 93.42% was determined, as shown in Figure 5(c).
In addition, it has inhibitory effects on anti-IgE-induced histamine release from human basophils and skin mast cells in vitro [115, 116].
A comparison of GSTM1 null gene polymorphism in the group of children with leukopenia also found to be significantly decreased WBC (p = 0.0001), neutrophil (p = 0.0001), basophil (p = 0.0449), lymphocyte (p = 0.0001), and monocyte (p = 0.0014) counts (Table 4).
Basophil count significantly decreased and remained in normal limits, in intervention group females when compared with control group females (P < 0.05).
only patients with CU and HT had anti-FceRI antibodies in their sera that could induce degranulation of normal basophils." (35) Interestingly, "Some sera from patients with CU and HT caused degranulation of normal basophils in the absence of anti-FceRI." (35)
Firstly, it inhibits the binding of IgE to the high-affinity IgE receptor (FcIuRI) on the surface of mast cells and basophils.3,4 Reduction in surface-bound IgE on FcIuRI-bearing cells limits the degree of release of allergic response mediators, as degranulation of mast cells and basophils would not be possible.13 Secondly, it binds to circulating IgE, irrespective of allergen specificity.
Patients n (*) Mean [+ or -] SD ([dagger]) Eosinophils 398 0.18 [+ or -] 0.14 Monocytes 400 0.57 [+ or -] 0.20 Lymphocytes 396 1.9 [+ or -]0.6 Neutrophils 400 4.1 [+ or -]1.5 Basophils 396 0.030 [+ or -] 0.017 Controls p-values n (*) Mean [+ or -] SD ([dagger]) ([partial derivative]) Eosinophils 394 0.19 [+ or -]0.15 n.s.
Downregulation of Fc(epsilon) RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody.
All WBC subtypes [monocytes, lymphocytes, neutrophils, eosinophils, and basophils; data available for 6,235 (89.5%) of participants with endotoxin data] were increased in current smokers and in subjects with cotinine [greater than or equal to] 10 ng/mL, whereas in subjects with COPD, all WBC subtypes were increased with the exception of lymphocytes, which were decreased (see Table S3).