FGF2

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FGF2

A gene on chromosome 4q26 that encodes fibroblast growth factor 2 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration. FGF2 plays a key role in various processes, including limb and nervous system development, wound healing and tumour growth, as well as angiogenesis. It is expressed in normal ovarian tissue and in hepatocellular carcinoma, but not in normal liver cells. FGF2 interacts with FGF receptors FGFR1, -2, -3 and -4.
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Generation of embryonic stem-like cells from in vivo -derived porcine blastocysts at a low concentration of basic fibroblast growth factor. Reprod Domest Anim 2018;53:176-85.
Wrathall, "Increased basic fibroblast growth factor expression following contusive spinal cord injury," Experimental Neurology, vol.
Developmental and regional expression of basic fibroblast growth factor mRNA in the rat central nervous system.
The SDF-1 receptor CXCR4 is expressed by endothelial cells, and its expression increases after treatment with VEGF or basic fibroblast growth factor [172].
Basic fibroblast growth factor enhances the capacity of bone marrow cells to form bone-like nodules in vitro FEBS Lett 1989; 250: 619-621.
Basic fibroblast growth factor is a testicular germ cell product which may regulate Sertoli cell function.
During the BTJ injury healing, the basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) were two important growth factors that affected injury healing (Lu et al., 2008; Thomopoulos et al., 2005; Wurgler-Hauri et al., 2007).
Growth factors such as transforming growth factor beta-1 (TGF-[beta]), vascular endothelial growth factor 11(VEGF), and basic fibroblast growth factor (bFGF) were reported to upregulate eNOS gene expression [6].
Determination of the Effect of Extracts on the Expression of Basic Fibroblast Growth Factor (bFGF) and Transforming Growth Factor-Beta (TGF-[beta])
Moscatelli, "High and low affinity binding sites for basic fibroblast growth factor on cultured cells: absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells," Journal of Cellular Physiology, vol.
Various devices, including microspheres, scaffolds, and hydrogels, have been used to bind and release angiogenic growth factors, such as vascular endothelial growth factor (VEGF), acidic and basic fibroblast growth factor (aFGF and bFGF), and platelet-derived growth factor (PDGF) [6, 7].
T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD41 and CD81 T cells.

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