stratum germinativum

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Related to Basal keratinocyte: stratum basale

stratum

[stra´tum, strat´um] (L.)

a sheetlike mass of tissue; see also lamina and layer.

stratum basa´le the deepest layer of the epidermis, composed of a single layer of basophilic cells. Called also basal layer of epidermis.

stratum cor´neum the outer horny layer of the epidermis, consisting of cells that are dead and desquamating. Called also horny layer.

stratum germinati´vum

1. the stratum basalis and stratum spinosum considered together; called also malpighian layer.

2. the lower layer of the nail, from which the nail grows; called also germinative layer.

stratum granulo´sum the cell layer of the epidermis lying between the stratum lucidum and the stratum spinosum. Called also granular layer.

1. the deep layer of the cortex of the cerebellum.

2. the layer of follicle cells lining the theca of the vesicular ovarian follicle; called also granular layer.

stratum lu´cidum the clear translucent layer of the epidermis, just beneath the stratum corneum. Called also clear layer.

stratum spino´sum the layer of the epidermis between the stratum granulosum and stratum basalis, marked by the presence of prickle cells; called also spinous layer and prickle-cell layer.

strat·um ba·sa·le ep·i·derm·i·dis

the deepest layer of the epidermis, composed of dividing stem cells and anchoring cells.

Synonym(s): basal cell layer, columnar layer, germinative layer, palisade layer, stratum basale (2) , stratum cylindricum, stratum germinativum

Farlex Partner Medical Dictionary © Farlex 2012

References in periodicals archive ?

The basal keratinocytes constitute the floor of the blister and do not lose their attachment to the basement membrane zone.

Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and IgE-Dependent and Immune Complex Reactions

Basal cell vacuolar degeneration and necrotic basal keratinocytes are seen in both LE and EM because of dysregulated apoptosis preceded by immunologic response initiated by unidentifid HSV, EBV or other viral infections crossreacting with lupus autoantigens.

ANA-negative systemic lupus erythematosus with targetoid lesions: Rowell syndrome or just a rare presentation of lupus erythematosus

There is increasing evidence that HPV is not cleared when lesions regress but as in COPV (45), CRPV (46) and BPV (47) infection remains in a latent state in a few basal keratinocytes (48-50).

Immune responses to human papilloma viruses

Moderate expression of TNF[alpha] was found in inflammation cells, the basal keratinocytes, and blister fluid (Figure 2).

Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis

The persistent expression of IL-17A in basal keratinocytes seems to induce target cell to secrete significant amounts of IL-6, resulting in high levels of circulating IL-6 and sIL-6/IL-6R heterodimers [23]; increased levels of local and systemic IL-6 influence IL-6R-alpha+ neutrophils and monocytes activity, leading to aberrant chemotaxis into lesional skin and formation of intraepidermal neutrophil microabscesses [23].

IL-6 as a druggable target in psoriasis: focus on pustular variants

Cytokeratin 14 stains normal basal keratinocytes of the epidermis (10,34) as well as follicular outer root sheath epithelium.

BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia

IL-1[alpha] induces growth factors in fibroblasts that can bind to receptors on the basal keratinocytes to promote proliferation [74].

Delineating molecular mechanisms of squamous tissue homeostasis and neoplasia: focus on p63

Today, there is a growing body of evidence that LP represents a T cell-mediated autoimmune damage to basal keratinocytes that express altered self- antigens on their surface.23 However, in regard to the periodic colocalization of lichen planus and vitiligo, diverse theories have been proposed; for example, one theory argues that suppressor T cells of LP become uninhibited by the change in antigen expression caused by vitiligo.

Coexistence of vitiligo, psoriasis and lichen planus in a single patient

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.

Therapeutic potential of retinoic acid metabolism blocking agents (RAMBAS) in skin disorders

PV and PF can appear identical on direct immunofluorescence, even though the blister cleavage plane is very high in PF and usually just above the basal keratinocytes in PV

Current treatment lacks evidence base

This histological feature is distinct from the melanocytes of freckles where normal number of melanocytes which are more pigmented due to increased melanin in basal keratinocytes (fig-1).1 While freckles are found almost exclusively on sun-exposed areas of the body, lentigenes may occur on all parts of the body and typically do not darken with sun exposure (as compared to freckles).

Generalized lentiginosis: an uncommon presentation

Mild reactive squamous atypia, particularly of basal keratinocytes, is quite common.

Cutaneous hypertrophic lupus erythematosus: a challenging histopathologic diagnosis in the absence of clinical information