Barrett's syndrome


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Barrett's syndrome

 [bar´ets]
peptic ulcer of the lower esophagus, often with stricture, due to the presence of columnar-lined epithelium in the esophagus, sometimes containing functional mucous cells, parietal cells, or chief cells, instead of the normal squamous cell epithelium. It is sometimes premalignant, followed by esophageal adenocarcinoma.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Barrett’s oesophagus

A histologically defined condition affecting roughly 2 million Americans, which develops in patients with GORD/GERD, which is characterised by metaplastic, premalignant intestinal columnar epithelium in the distal oesophagus, and may accompanied by peptic ulceration, typically a sequel of chronic reflux. It carries a 35-40-fold increased risk of oesophageal adenocarcinoma, is accompanied by dysplasia, and has a prognosis similar to that of squamous cell carcinoma (14.5% 5-year survival).
 
Endoscopy
Barrett’s changes include proximal migration of the squamocolumnar Z-line, and patchy areas corresponding to single layered columnar cells in intimate contact with underlying blood vessels.

Management
Low-grade dysplasia: Epithelial radiofrequency ablation.
High-grade dysplasia: Epithelial radiofrequency ablation, oesophagectomy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Barrett's syndrome

Also called Barrett's esophagus or Barrett's epithelia, this is a condition where the squamous epithelial cells that normally line the esophagus are replaced by thicker columnar epithelial cells.
Mentioned in: Heartburn
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Patient discussion about Barrett's syndrome

Q. Cn barret esophagous be cured? I was diagnosed with barretts esophagus several years ago, and so far keeps on the routine follow up. I met some other guy with same condition and he told after his doctor prescribed him with some anti-reflux meds, in the last endoscopy they found normal esophagus, and that he thinks he's now cured. Is that possible?

A. Anti-reflux treatment may lower the risk of cancer a little, but it won't cure it, so there's still a need for refular follow-up.

More discussions about Barrett's syndrome
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