Barrett's oesophagus

Barrett’s oesophagus

A histologically defined condition affecting roughly 2 million Americans, which develops in patients with GORD/GERD, which is characterised by metaplastic, premalignant intestinal columnar epithelium in the distal oesophagus, and may accompanied by peptic ulceration, typically a sequel of chronic reflux. It carries a 35-40-fold increased risk of oesophageal adenocarcinoma, is accompanied by dysplasia, and has a prognosis similar to that of squamous cell carcinoma (14.5% 5-year survival).
 
Endoscopy
Barrett’s changes include proximal migration of the squamocolumnar Z-line, and patchy areas corresponding to single layered columnar cells in intimate contact with underlying blood vessels.

Management
Low-grade dysplasia: Epithelial radiofrequency ablation.
High-grade dysplasia: Epithelial radiofrequency ablation, oesophagectomy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Barrett's oesophagus

A gullet (oesophagus) in which long-standing inflammation (oesophagitis) has led to a change in the nature of the lining mucus membrane to a columnar form. An ulcer may develop (Barrett's ulcer) and lead to narrowing (stricture) or possibly cancer. (Norman Rupert Barrett, Australian-born English surgeon, 1903–1979).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Out of 100 people with Barrett's oesophagus in the UK, up to 13 could go on to develop oesophageal cancer.
It's Barrett's oesophagus. It has badly eroded due to alcohol drinking.
One in five people suffer from acid reflux and one in 10 of these develop Barrett's oesophagus, where the cells of the gullet grow abnormally.
An important concept emerging from the consensus process is that of GERD being a spectrum disease that can run from symptomatic GERD through the potential complications of oesophagitis, haemorrhage and stricture formation, to Barrett's oesophagus and oesophageal adenocarcinoma.
Increasing incidence of Barrett's oesophagus in the general population.
The researchers utilised tissue samples from patients with Barrett's oesophagus, high-grade dysplasia and oesophageal cancer to detect and select targets for blood analysis using a proteomics profiling technology.
Proton pump inhibitor use may not prevent high-grade dysplasia and oesophageal adenocarcinoma in Barrett's oesophagus: a nationwide study of 9883 patients.
If left untreated, this can lead to a condition called Barrett's oesophagus, which in turn can be a precursor of oesophageal cancer.
Flejou, "Barrett's oesophagus: from metaplasia to dysplasia and cancer," Gut, vol.
Barrett's oesophagus (BO) is defined as the occurrence of metaplastic, specialised columnar epithelium lining the distal part of the oesophagus.
Kieran Peart, 14, was diagnosed with Barrett's oesophagus, a pre-cancer of the gullet, three years ago.
Miniprobe confocal laser microscopy for the detection of invisible neoplasia in patients with Barrett's oesophagus. Gut.