Barrett’s oesophagusA histologically defined condition affecting roughly 2 million Americans, which develops in patients with GORD/GERD, which is characterised by metaplastic, premalignant intestinal columnar epithelium in the distal oesophagus, and may accompanied by peptic ulceration, typically a sequel of chronic reflux. It carries a 35-40-fold increased risk of oesophageal adenocarcinoma, is accompanied by dysplasia, and has a prognosis similar to that of squamous cell carcinoma (14.5% 5-year survival).
Barrett’s changes include proximal migration of the squamocolumnar Z-line, and patchy areas corresponding to single layered columnar cells in intimate contact with underlying blood vessels.
Low-grade dysplasia: Epithelial radiofrequency ablation.
High-grade dysplasia: Epithelial radiofrequency ablation, oesophagectomy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Barrett's oesophagusA gullet (oesophagus) in which long-standing inflammation (oesophagitis) has led to a change in the nature of the lining mucus membrane to a columnar form. An ulcer may develop (Barrett's ulcer) and lead to narrowing (stricture) or possibly cancer. (Norman Rupert Barrett, Australian-born English surgeon, 1903–1979).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005