Barnes Akathisia Scale


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Barnes Akathisia Scale

A testing device—range of 0 to 14, with higher scores indicating greater severity—used to evaluate restlessness related to drug therapy.
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Extrapyramidal symptoms were evaluated using the Simpson-Angus scale (Simpson and Angus 1979), Barnes Akathisia scale (Barnes 1989), and abnormal involuntary movement scale (AIMS) (National Institute of Mental Health 1976b).
5), the mean Barnes Akathisia Scale index score was 0.
A significant moderate effect of NAC was also seen on the Barnes Akathisia Scale, he reported.
The safety and efficacy of intramuscular ziprasidone were evaluated by using the following instruments: Behavioral Activity Rating Scale (BARS) (responders were defined a priori as having a [greater than or equal to] 2-point reduction in BARS score); Clinical Global Impressions, severity of illness (CGI-S) and global improvement (CGI-I) scales; Positive and Negative Syndrome Scale (PANSS); Barnes Akathisia Scale (BAS); and Simpson-Angus Scale (SAS) (4).
Additionally, iloperidone also had a similar akathisia profile to placebo, whereas ziprasidone was associated with a significant worsening of akathisia versus placebo on the Barnes Akathisia Scale (BAS), with 26 percent of patients experiencing a worsening of akathisia.
1) Positive and Negative Symptom Scale Total (PANSS-T) (2) PANSS Negative (PANSS-N), PANSS Positive (PANSS-P) (3) Brief Psychiatric Rating Scale (BPRS) (4) Clinical Global Impression Severity (CGI-S) (5) Clinical Global Impression of Change (CGI-C) (6) Barnes Akathisia Scale (BAS) (7) Extrapyramidal Symptom Ratings Scale (ESRS)
Patients were evaluated using the Barnes Akathisia Scale (BAS), a four-item rating scale widely used to assess this particular side effect of antipsychotic drugs.
Table Showing Results of ACP-103 on Haloperidol-Induced Akathisia Versus Placebo as Measured by the Barnes Akathisia Scale (BAS)
minimal drug-induced akathisia compared with clinically significant akathisia experienced by risperidone patients (scores on the Barnes Akathisia Scale, where a score of 0 represents no drug-induced akathisia, decreased from 1.
No significant changes were observed in Abnormal Involuntary Movement Scale (AIMS), Simpson-Angus Scale (SAS), or Barnes Akathisia Scale (BAS) at baseline and at the end of the study.
Safety and tolerability were also assessed weekly using the Simpson-Angus Scale (SAS), Barnes Akathisia Scale (BAS), Abnormal Involuntary Movement Scale (AIMS), laboratory tests and vital signs.