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A gene on chromosome 22q12.2 that encodes a putative regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, which plays a key role in tumour suppression by restricting proliferation and promoting apoptosis. NF2 may act as a membrane-stabilising protein, and it may inhibit PI3 kinase by binding to AGAP2 and downregulating its stimulating activity. NF2 suppresses cell proliferation and tumourigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Molecular pathology
NF2 defects cause:
• Neurofibromatosis 2;
• Schwannomatosis; and
• Mesothelioma (some cases).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Bilateral acoustic neurofibromatosis. See Neurofibromatosis, type 2.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
BANF is expected to have increased power as the city council moves towards devolved decision-making.
At the group's annual meeting officers outlined the full range of support they had received from BANF including setting up the constitution, producing websites, printing leaflets and delivering newsletters.
He claims his dismissal was driven by his activities as a "whistleblower" when he attempted to raise issues about the probity of BANF - which has received about pounds 200,000 in funding from the city council over the past year.
However, a BANF spokesman said: 'The BANF management committee has decided not to issue the manager of BANF, Mick Rice, with a further contract following the completion of his current 12-month fixed term contract on August 31 2005.'
My union has a number of members employed by both BANF and BCEN and we are giving them our support to try to retain their jobs.
Among those hit by redundancy is BANF administrator and former Labour councillor Mick Rice who has already received official notice to quit his pounds 35,000 a year job.
A new, 14-night Canadian Rockies itinerary - taking in Seattle, Vancouver, Kamloops, Jasper, Banf Calgary, Kalispell, Spokane and Mt Ranier National Park - costs pounds 696 per person (twin share) for the room-only hotel accommodation and route notes (c hildren under 11 travel and stay free when sharing with two adults).
Oklahoma City-based BancFirst Corporation (NASDAQ GS: BANF) has announced a plan to acquire CSB Bancshares Inc and its subsidiary, Bank of Commerce.
BancFirst Corporation (NASDAQ GS: BANF) said it has reported results of the first quarter 2015 that includes net income of USD16.4 million, or USD1.03 diluted earnings per share.
Readers can obtain up-to-date information on the SAVE BANF campaign and also sign the e-petition to senior councillors at
Banff Springs Hotel, PO Box 960, Banf Alberta, Canada TOL OCO, telephone (403) 762 2211.
BancFirst Corporation (NASDAQ GS: BANF) has reported net income of USD16.3m, or USD1.03 diluted earnings per share, for the first quarter of 2015, compared to net income of USD14.7m, or USD0.94 diluted earnings per share, for the first quarter of 2014.