EPB41

(redirected from Band 4.1)
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EPB41

A gene on chromosome 1p33-p32 that encodes protein 4.1, which, with spectrin and actin, constitutes the red cell membrane cytoskeletal network. This network plays a critical role in red cell shape and deformability.

Molecular pathology
EPB41 mutations cause elliptocytosis type 1.
References in periodicals archive ?
N-terminal (JH 7) of Jak molecule has a receptor binding site while C-terminal (JH 1) is responsible for catalytic activity.1,3 These regions have four functional domains, which includes a FERM (band 4.1, ezrin, radixin, moesin), an SH2 (Src homology 2) like domain, a tyrosine kinase and kinase-like pseudokinase domain.4,6-8
Hamasaki, "Abnormal erythrocyte band 4.1 protein in myelodysplastic syndrome with elliptocytosis," British Journal of Haematology, vol.
(Hanns Eisler Gesamtausgabe; Serie IX : Schriften; Band 4.1).