Aminosalicylates, such as mesalamine (Lialda), mesalamine extended-release (Apriso), olsalazine (Dipentum), and balsalazide
Common aminosalicylates used in IBD include sulfasalazine, balsalazide
, mesalamine, and olsalazine.
Children were defined as having IBD if they had either three or more health care visits for Crohn's disease or ulcerative colitis during the study's time frame, or "at least one health care contact for Crohn's disease or ulcerative colitis and at least one pharmacy claim for any of the following medications: mesalamine, olsalazine, balsalazide
, sulfasalazine, 6-mercaptopurine, azathioprine, methotrexate, enteral budesonide, or biologies (infliximab, adalimumab, certolizumab, or natalizumab).
He had been maintained on balsalazide
(5-ASA), metronidazole, adalimumab, and omeprazole.
This group includes mesalamine, or 5-aminosalicylic acid (5-ASA), sulphasalazine, olsalazine, and balsalazide
The prodrugs sulfasalazine, olsalazine and balsalazide
rely on colonic bacterial enzymes to metabolize the inactive precursor to the active drug mesalazine.
has announced the introduction of balsalazide
disodium capsules, 750 mg.
tablets, Granulated Mesalamine and SANVAR (600 ug vials vapreotide acetate powder) are under development.
Two other agents in this class, balsalazide
(Colazal) and olsalazine (Dipentum), are broken down in the colon to 5-ASA.
Three medicines are used for treating an acute attack: Aminosalicylates (such as balsalazide
, mesalazine, olsalazine, sulfasalazine), Corticosteroids (budesonide, hydrocortisone, prednisolone) and Immunosuppressants (azathioprine, ciclosporin, mercaptopurine) Rest is important during an attack to allow healing to take place.
and azathioprine or 6-mercaptopurine: evidence for a potentially serious drug interaction.
Active UC should be treated initially with systemic aminosalicylate drugs (such as sulfasalazine, olsalazine, balsalazide
, and mesalamine) or with corticosteroids.