Balkan Endemic Nephropathy


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A chronic tubulointerstitial nephropathy endemic to the littoral regions of the Danube, occurring in the Balkans—Bulgaria, Croatia, Romania, Serbia
Etiology Unknown; converging lines of evidence suggest a link to long-term consumption of food contaminated with aristolochic acid
Prognosis The natural course of the disease is characterised by universal development of end-stage renal disease and the frequent development of upper urinary tract tumours; most patients die within 10 yrs of onset
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References in periodicals archive ?
Molecular and epidemiological approaches to the etiology of urinary tract tumors in an area with Balkan endemic nephropathy. J Environ Pathol Toxicol Oncol., 15(2-4): 201-7.
Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary tract tumours in Bulgaria.
William Orem, a USGS geochemist from Reston, Virginia, has been studying Balkan endemic nephropathy (BEN), which occurs in certain areas in the Balkans.
And an often-fatal kidney disease known as Balkan endemic nephropathy, which affects people who live in rural areas of Bulgaria, Romania, and Yugoslavia, has been linked with ochratoxin A, a mycotoxin that can contaminate beans, grains, and some of the meat of pigs hat eat tainted grain.
van Ypersele de Strihou, "Chinese herbs nephropathy: a clue to Balkan endemic nephropathy?" Kidney International, vol.

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