Bactroban


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mupirocin (pseudomonic acid, pseudomonic acid A)

Bactroban, Bactroban Nasal 2%, Taro-Mupirocin (CA)

Pharmacologic class: Dermatologic agent

Therapeutic class: Anti-infective, topical

Pregnancy risk category B

Action

Inhibits bacterial protein and RNA synthesis by reversibly and specifically binding to bacterial isoleucyl-transfer RNA synthetase. Bactericidal.

Availability

Intranasal ointment: 2.15%

Topical cream: 2%

Topical ointment: 2%

Indications and dosages

Impetigo

Adults and children ages 2 months to 16 years: Apply a small amount of ointment topically t.i.d. for 3 to 5 days. Reevaluate if no response.

Infected traumatic skin lesions

Adults and children ages 3 months to 16 years: Apply a small amount of cream topically t.i.d. for 10 days.

Nasal colonization of methicillin-resistant Streptococcus aureus

Adults and children ages 12 and older: Apply intranasal ointment (half of single-use tube to each nostril) topically to anterior nares b.i.d. for 5 days.

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• moderate or severe renal impairment (with large doses)

• breastfeeding patients

• children younger than age 12 (intranasal ointment), younger than age 3 months (cream), or younger than age 2 months (ointment).

Administration

• After intranasal application, press nares together repeatedly to distribute drug.

• Avoid contact with eyes.

• Discontinue use if sensitization or severe local irritation occurs.

• If desired, cover affected area with gauze dressing after applying cream or ointment.

• Don't use intranasal form with any other nasal spray.

• Don't use Bactroban ointment on mucosal surfaces. Use Bactroban Nasal (mupirocin calcium ointment) intranasally.

• Know that although mupirocin isn't absorbed systemically, polyethylene glycol (its water-miscible ointment base) may be absorbed from open wounds and damaged skin and may be excreted by the kidneys.

Adverse reactions

CNS: headache (with intranasal use)

EENT: rhinitis, nasal stinging or burning, pharyngitis (all with intranasal use)

GI: mouth and lip sores

Skin: pruritus (with intranasal use); dry skin, rash, redness, stinging or pain, secondary wound infection

Other: taste disorders (with intranasal use)

Interactions

None significant

Patient monitoring

• Monitor for drug efficacy.

Patient teaching

• Instruct patient to wash affected area with soap and water and dry it thoroughly, then apply small amount of drug to area and rub in gently. If desired, tell him to apply gauze dressing.

• Advise patient to complete entire course of therapy, even if symptoms disappear. Tell him to try not to miss doses.

• If patient misses a dose, tell him to apply dose as soon as he remembers. However, if it's almost time for next dose, advise him to skip missed dose and resume regular dosing schedule.

• Advise patient to contact prescriber if skin infection doesn't improve within 3 to 5 days or if it worsens.

• Caution patient not to apply drug to eye or mucous membranes (except nasal form for intranasal use).

• As appropriate, review all other significant adverse reactions.

Bactroban

(băk′trə-băn′)
A trademark for the drug mupirocin calcium.

Bactroban

A topical antibiotic for treating traumatic skin lesions with secondary infection by susceptible strains of Staphylococcus aureus, methicillin-resistant S aureus (MRSA) and Streptococcus pyogenes,

Bactroban®

Mupirocin cream A topical antibiotic for treating traumatic skin lesions with 2º infection by susceptible strains of Staphylococcus aureus, methicillin-resistant S aureus–MRSA, Streptococcus pyogenes
References in periodicals archive ?
Group B comprised 76 patients who underwent septoplasty and who were packed with mupirocin cream (Bactroban 2% cream; GlaxoSmithKline, Istanbul, Turkey)-soaked PVA sponge Merocel (Medtronic, Connecticut, USA) with integral airway in both nasal cavities.
Bactroban is a topical anti-infection ointment used to treat skin infections.
Ademas se detecta en frotis nasal la aparicion de Staphilococus Aureus por lo que se administra Bactroban intranasal [R] una aplicacion en cada fosa nasal dos veces al dia, los primeros cinco dias de cada mes.
Ortiz said the company allowed several drugs to be adulterated between 2001 and 2005, including Paxil CR, a skin-infection ointment called Bactroban, an anti-nausea drug called Kytril, and a diabetes drug called Avandamet.
Bactroban is a registered trademark of Smithkline Beecham Pharmaceuticals.
Your GP can prescribe antibiotic creams such as Naseptin or Bactroban, which, when applied in and around the nostrils, are effective in treating infection and will also help coat, moisturise and protect the nasal mucosa.
The efficacy of Bactroban ointment in the treatment of MARS Staphylococcus aureus burn wound infections in children.
He predicted that the topical pleuromutilin will fill a role in clinical practice similar to that once occupied by mupirocin (Bactroban), which was widely prescribed for the topical therapy of secondarily infected inflammatory skin diseases until resistance became a major problem--a not-surprising development considering the drug has been marketed in the United States for 18 years.
The doctor can prescribe some cream called Bactroban Nasal and, if need be, antibiotics.
Treatment to eliminate nasal carriage in culture-positive persons was given after randomization, by using either intranasal mupirocin calcium 2% ointment (Bactroban, Glaxo SmithKline, Philadelphia, PA) or sodium fusidate 2% ointment (Fucidin, Leo Pharmaceutical, Ballerup, Denmark), twice a day for a week.