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mupirocin (pseudomonic acid, pseudomonic acid A)

Bactroban, Bactroban Nasal 2%, Taro-Mupirocin (CA)

Pharmacologic class: Dermatologic agent

Therapeutic class: Anti-infective, topical

Pregnancy risk category B


Inhibits bacterial protein and RNA synthesis by reversibly and specifically binding to bacterial isoleucyl-transfer RNA synthetase. Bactericidal.


Intranasal ointment: 2.15%

Topical cream: 2%

Topical ointment: 2%

Indications and dosages


Adults and children ages 2 months to 16 years: Apply a small amount of ointment topically t.i.d. for 3 to 5 days. Reevaluate if no response.

Infected traumatic skin lesions

Adults and children ages 3 months to 16 years: Apply a small amount of cream topically t.i.d. for 10 days.

Nasal colonization of methicillin-resistant Streptococcus aureus

Adults and children ages 12 and older: Apply intranasal ointment (half of single-use tube to each nostril) topically to anterior nares b.i.d. for 5 days.


• Hypersensitivity to drug or its components


Use cautiously in:
• moderate or severe renal impairment (with large doses)
• breastfeeding patients
• children younger than age 12 (intranasal ointment), younger than age 3 months (cream), or younger than age 2 months (ointment).


• After intranasal application, press nares together repeatedly to distribute drug.
• Avoid contact with eyes.
• Discontinue use if sensitization or severe local irritation occurs.
• If desired, cover affected area with gauze dressing after applying cream or ointment.
• Don't use intranasal form with any other nasal spray.
• Don't use Bactroban ointment on mucosal surfaces. Use Bactroban Nasal (mupirocin calcium ointment) intranasally.
• Know that although mupirocin isn't absorbed systemically, polyethylene glycol (its water-miscible ointment base) may be absorbed from open wounds and damaged skin and may be excreted by the kidneys.

Adverse reactions

CNS: headache (with intranasal use)

EENT: rhinitis, nasal stinging or burning, pharyngitis (all with intranasal use)

GI: mouth and lip sores

Skin: pruritus (with intranasal use); dry skin, rash, redness, stinging or pain, secondary wound infection

Other: taste disorders (with intranasal use)


None significant

Patient monitoring

• Monitor for drug efficacy.

Patient teaching

• Instruct patient to wash affected area with soap and water and dry it thoroughly, then apply small amount of drug to area and rub in gently. If desired, tell him to apply gauze dressing.
• Advise patient to complete entire course of therapy, even if symptoms disappear. Tell him to try not to miss doses.
• If patient misses a dose, tell him to apply dose as soon as he remembers. However, if it's almost time for next dose, advise him to skip missed dose and resume regular dosing schedule.
• Advise patient to contact prescriber if skin infection doesn't improve within 3 to 5 days or if it worsens.
• Caution patient not to apply drug to eye or mucous membranes (except nasal form for intranasal use).
• As appropriate, review all other significant adverse reactions.


A trademark for the drug mupirocin calcium.


A topical antibiotic for treating traumatic skin lesions with secondary infection by susceptible strains of Staphylococcus aureus, methicillin-resistant S aureus (MRSA) and Streptococcus pyogenes,


Mupirocin cream A topical antibiotic for treating traumatic skin lesions with 2º infection by susceptible strains of Staphylococcus aureus, methicillin-resistant S aureus–MRSA, Streptococcus pyogenes
References in periodicals archive ?
Bactroban is a topical anti-infection ointment used to treat skin infections.
Ademas se detecta en frotis nasal la aparicion de Staphilococus Aureus por lo que se administra Bactroban intranasal [R] una aplicacion en cada fosa nasal dos veces al dia, los primeros cinco dias de cada mes.
He said that no patients appeared to have been harmed by the quality problems at the plant, which included failing to ensure that Bactroban and Kytril were free of contamination from microorganisms and causing Paxil controlled release tablets to split, causing the potential distribution of tablets that did not have any therapeutic effect.
Todos ellos se trataron con pomada Bactroban nasal, durante una semana.
Two, if we have a player who is infected with MRSA, would you prophylactically use [mupirocin] Bactroban nasally on the rest of the team to try and prevent colonization?
I had something called MRSA in my nose, but the medicine I was given - Bactroban - didn't agree with me.
The civil settlement of $600 million resolves charges that GSK released to the market Bactroban ointment, a topical antibiotic used to treat skin infections in babies, that contained microorganisms and Kytril injection, an anti-nausea drug used by cancer patients, that was not sterile.
4 Bactroban Will Decline in Revenues During the Forecast Period
9 Bactroban Revenue Forecast ($m), 2011-2023 Figure 4.
8 Bactroban Sales Forecast ($m), AGR (%), CAGR (%), 2010-2022
Leyden has also been instrumental in the development, testing and commercialization of Accutane, Bactroban, Nizoral, Cleocin, Benzamycin, Benzaclin, Minocin and the use of bicarbonate to control body odor.