It was observed that the use of Lactobacillus plantarurn decreased intestinal epithelial apoptosis and oxidative stress, while simultaneously strengthening intercellular adhesion supporting the mucosal integrity; further the use of glutamine and probiotics reduced bacterial translocation
. Improvements-were found in all the biochemical, pathological, and microbiological findings in rats that underwent choledoch ligation [25-27].
Role of intestinal bacterial overgrowth and intestinal motility in bacterial translocation
in experimental cirrhosis.
Obstructive jaundice alters kuppfer cell function independent of bacterial translocation
. J Surg Res 1998; 80: 205-209.
from gastrointestinal tract to systemic organs creates the possibility of infection and sepsis in a great number of pathologic entities.
Lario et al., "O153 the farnesoid X receptor agonist, obeticholic acid, improves intestinal antibacterial defense and reduces gut bacterial translocation
and hepatic fibrogenesis in CCl4-cirrhotic rats with ascites," Journal of Hepatology, vol.
In addition, a leaky gut exacerbates T1D either indirectly via beta-cell damage, due to bacterial translocation
and related antigen presentation , or directly via beta-cell function impairment mediated by microbial toxins, such as streptozotocin .
Effects of two fluid resuscitations on the bacterial translocation
and inflammatory response of small intestine in rats with hemorrhagic shock.
Granger, "Hemorrhagic shock-induced bacterial translocation
: the role of neutrophils and hydroxyl radicals," Journal of Trauma-Injury Infection & Critical Care, vol.
These findings may indicate that the responsible underlying mechanism for pneumonia in cases where intra-abdominal pressure is highly elevated could be bacterial translocation
via the bloodstream, besides the aspiration of gastrointestinal content which is a known pathophysiologic mechanism.
* Traumatic SCI causes bacterial translocation
(movement of bacteria from gut into sterile tissues throughout the body) and dysbiosis.
Gut origin of sepsis: A prospective study investigating associations between bacterial translocation
, gastric microflora, and septic morbidity.