Bannayan-Riley-Ruvalcaba syndrome

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Bannayan-Riley-Ruvalcaba syndrome

A rare autosomal dominant disorder (OMIM:153480) characterised by: excessive growth before and after birth; increased birth weight and length; macrocephaly often with scaphocephaly; normal intelligence or mild mental retardation; multiple subcutaneous hamartomas, lipomas, macrocephaly and hemangiomas; ocular defects (strabismus, ocular hypertelorism, exotropia and/or pseudopapilledema, hypotonia); drooling; delayed speech development and/or significant delay in developmental milestones (sitting, standing, walking); hamartomatous polyps in gastrointestinal tract and oropharynx; marbled  skin pigmentation (cutis marmorata and pigmented macules on the penis or vulva); and myopathy.

Molecular pathology
Like Peutz-Jeghers syndrome, juvenile polyposis, Cowden syndrome, Proteus syndrome and Proteus-like syndrome, Bannayan-Riley-Ruvalcaba syndrome is caused by mutations of PTEN, all of which are known as PTEN hamartoma-tumour syndromes.
References in periodicals archive ?
The first dividend of Bzs 9 per share is expected to be paid in February
Nevertheless, studies showed that no distinguishing effects were found between BZs and placebo in treating PTSD in the short-term and consuming BZs cannot prevent development of PTSD in the long term [52-54].
For example, BZs may be used to moderate the effects of drugs such as cocaine (Rigg & Ibanez 2010).
Finally, BZs are not recommended for the short- or long-term treatment of sleep disturbance in PTSD by the VA/DOD CPG [12] because of a lack of proven efficacy and the risks for habituation and dependence.
All of these agents are probably equally effective for generalized anxiety disorder, as well as for unipolar depression and for tapering off BZs.
Tensions in upper management have become noticeable ever since Video Cable Vision became the target of a takeover bid by BZS, Inc., one of the nation's up-and-coming telecommunications companies.
OQIC, a premier insurer in Oman, is offering 25 million offer shares at an offer price of 160 baisa per offer share, (comprising a nominal value of Bzs 100 per offer share, premium of Bzs 58 per offer share and offer expenses of Bzs 2 per offer share).
On 31 December 2016, SMNP's share price reached 712 bzs per share.
share value at the IPO has been fixed at Bzs 110 (comprising nominal value of Bzs 100, share premium of Bzs 8 and issue expenses of Bzs 2).
All paperbacks sell at 500 bzs each and hardbacks sell at OMR1 each.
The offer price for each share has been fixed at Bzs 102, which comprises the nominal value of Bzs 100 per share and a Bzs 2 per share contribution towards the issue expenses of the IPO.
Fixed line customers can call more than 70 countries including GCC, Indian sub-continent, and a majority of Arab and European countries for OR 0.065 Bzs ($0.17) per minute.