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Abbreviation for Bruton tyrosine kinase.


A gene on chromosome Xq21.33-q22 that encodes a protein which plays a central role in B-cell development, differentiation and signalling. Binding of antigens to the B-cell antigen receptor (BCR) triggers signalling that leads to B-cell activation. 

Molecular pathology
Defects of BTK cause X-linked agammaglobulinaemia (OMIM:300755), as well as X-linked hypogammaglobulinaemia and isolated growth hormone deficiency (OMIM:307200).

Bruton's agammaglobulinemia tyrosine kinase (Btk)

An enzyme vital for the maturation of B cells.
References in periodicals archive ?
Likewise, Philippe Garsuault, Chief Executive Officer of BPCE International et Outre-mer and BTK President of the Board of Directors, pointed out that during the last three years we have continued to expand our business lending.
The BTK increases the strategic importance of Azerbaijan by enabling it to become a transport hub between Europe and Asia.
Azerbaijani President Ilham Aliyev called the BTK Railway a "historic project" and described the new period by saying, "It will increase the geopolitical importance of our countries and open up new opportunities for us.
And then larger volumes will be transported," Azerbaijan President Aliyev said, adding that "the BTK railway is becoming an important part of Eurasia's transport map.
RXC005 (reversible BTK inhibitor) is focused on treating patients with chronic lymphocytic leukaemia who have become resistant to ibrutinib, and will be entering studies in the coming months to enable submission of an Investigational New Drug application in 2018.
Here we report a roughly 22-month clinical response of non-metastatic RCC to ibrutinib, a BTK inhibitor.
The financing is expected to help BTK expand its loan portfolio and reach out to a greater number of smaller businesses, IFC said in a statement.
3 MTD) for BTK (Groupe BPCE) to help extend loans to small and medium-sized enterprises (SMEs) and sustain economic growth in Tunisia.
Speaking at a conference on the BTK in Baku, Elvan pointed out historical importance of the project saying that they establish a line of brotherhood and sympathy in addition to a line between the countries.
Council of State approved the tender and sent it to BTK on Thursday.
He helped defuse a jail riot, identified four Mexican teens who had used tourist river rafters as shooting targets, arrested a version of the BTK killer, and brought to justice hundreds of garden-variety criminals.
Re 'Chilling details emerge at BTK killer's hearing'' (Aug.