BST2

BST2

A gene on chromosome 19p13.1 that encodes bone marrow stromal cell antigen-2, the function of which is currently unknown, but which may play a role in pre-B-cell growth, in sorting secreted proteins and in retroviral defense, blocking the release of enveloped virus from the cell surface. It is active against retroviruses, filoviruses, arenaviruses and herpesviruses.
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BST2 is associated with growth and development of B-cells.
4) confirmed that DEFA6, B-cell CLL/lymphoma 11A (BCL11A), interleukin 33 (IL33), BMP7, ATP binding cassette subfamily B member 1 (ABCB1), CCND2, TNFRSF1B, fibronectin 1 (FN1), semaphorin 6A (SEMA6A), and galanin (GAL) were upregulated and that PDGFC, prostaglandin-endoperoxide synthase 2 (PTGS2), Wnt family member 11 (WNT11), transforming growth factor beta 2 (TGFB2), dickkopf WNT signaling pathway inhibitor 1 (DKK1), bone marrow stromal cell antigen 2 (BST2), GATA binding protein 2 (GATA2), gap junction protein beta 6 (GJB6), SMARCA1, and ADAM metallopeptidase with thrombospondin type 1 motif 6 (ADAMTS6) were downregulated in CTC-MCC-41 cells compared with HT-29 cells.
report their investigation of bone marrow stromal antigen 2 (BST2; also known as CD317, tetherin, and HM1.24) as a plasma biomarker in 152 patients with CRC.
The expression of bone marrow stromal protein 2 (BST2), which can be associated with the development of bone metastasis in human breast cancer, is significantly increased in bone metastatic breast cancer cell lines and tumor tissue compared with nonbone metastatic breast cancer cell lines.
PHD (Fort Wayne, IN) has introduced the new Series BST2 Transfer Arm.
Abbreviations, CD numeration, and alternate names: DEC-205 (CD205), B220 (CD45R), PDCA-1 (plasmacytoid DC Ag-1; CD317; Bst2), Siglec H (Sialic acid-binding immunoglobulin-like lectin H), Langerin (CD207), CD141 (BDCA-3), CD1c (BDCA-1), and CD303 (BDCA-2).
(143-146) One study has suggested Serpine10 and BIN1 as potential markers and BST2 and LCK as potential therapeutic molecular targets.
This set of IFN-stimulated genes (ISGs) contained several genes with previously known direct antiviral activity, such as APOL9, BST2 (Tetherin), DDX58 (RIG-1), EIF2AK2 (PKR), IFITM3, ISG15, MX2, OAS-1, PARP12, or TRIM.