BST1

A gene on chromosome 4p15 that encodes bone marrow stromal cell antigen-1, a glycosylphosphatidylinositol-GPI-anchored molecule that facilitates pre-B-cell growth by synthesising cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores.

Molecular pathology
The polyclonal B-cell changes in rheumatoid arthritis may be partly due to BST1 overexpression in stromal cells.

References in periodicals archive ?

Mutations in the BST1 gene of Saccharomyces cerevisiae disrupt proper sorting at the endoplasmic reticulum (ER): a subset of secretory proteins are transported with reduced kinetics, and resident proteins leak more rapidly from the ER.

Cell and molecular biology section. (Abstracts of Papers Presented at the 111th Meeting)

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