BST1

BST1

A gene on chromosome 4p15 that encodes bone marrow stromal cell antigen-1, a glycosylphosphatidylinositol-GPI-anchored molecule that facilitates pre-B-cell growth by synthesising cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores.

Molecular pathology
The polyclonal B-cell changes in rheumatoid arthritis may be partly due to BST1 overexpression in stromal cells.
References in periodicals archive ?
The polymorphisms located within common susceptibility variants--the SNCA, MAPT, LRRK2, GBA, PARK16, BST1, DGKQ, and STK39 genes--exhibit the strongest association with sporadic PD [8-11].
The rs13388259 Intergenic Polymorphism in the Genomic Context of the BCYRN1 Gene Is Associated with Parkinson's Disease in the Hungarian Population
Sawada et al., "Novel SCRG1/ BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells," Scientific Reports, vol.
Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts
Simpson et al., "A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma," Autism Research, vol.
CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
It was reported that transcription factors such as Nanog, Rex1, Fzd9, Oct4, Sox2 and Bst1 genes were essential in pluripotency maintenance as well as self-renewal (Safwani et al., 2012).
Effects of serial passage on the characteristics and chondrogenic differentiation of canine umbilical cord matrix derived mesenchymal stem cells
The bst1 gene of Saccharomyces cerevisiae plays an important role in this process at the endoplasmic reticulum (ER).
Abstracts of papers presented at the 113th meeting
Recently, we proposed a novel mechanism for the promotion of the migration of BM-MSCs via the scrapie responsive gene 1 (SCRG1)/bone marrow stromal cell antigen 1 (BST1) axis through the activation of the FAK/PI3K/Akt signaling pathway in an autocrine/paracrine manner [25].
Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts
Hannun, "The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase," Journal of Biological Chemistry, vol.
S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling
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