BST1

BST1

A gene on chromosome 4p15 that encodes bone marrow stromal cell antigen-1, a glycosylphosphatidylinositol-GPI-anchored molecule that facilitates pre-B-cell growth by synthesising cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores.

Molecular pathology
The polyclonal B-cell changes in rheumatoid arthritis may be partly due to BST1 overexpression in stromal cells.
References in periodicals archive ?
The polymorphisms located within common susceptibility variants--the SNCA, MAPT, LRRK2, GBA, PARK16, BST1, DGKQ, and STK39 genes--exhibit the strongest association with sporadic PD [8-11].
Sawada et al., "Novel SCRG1/ BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells," Scientific Reports, vol.
Simpson et al., "A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma," Autism Research, vol.
It was reported that transcription factors such as Nanog, Rex1, Fzd9, Oct4, Sox2 and Bst1 genes were essential in pluripotency maintenance as well as self-renewal (Safwani et al., 2012).
The bst1 gene of Saccharomyces cerevisiae plays an important role in this process at the endoplasmic reticulum (ER).
Recently, we proposed a novel mechanism for the promotion of the migration of BM-MSCs via the scrapie responsive gene 1 (SCRG1)/bone marrow stromal cell antigen 1 (BST1) axis through the activation of the FAK/PI3K/Akt signaling pathway in an autocrine/paracrine manner [25].
Hannun, "The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase," Journal of Biological Chemistry, vol.