ABCB11

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ABCB11

A gene on chromosome 2q24 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, MDR/TAP subfamily, which is involved in multi-drug resistance and is major canalicular bile salt export pump
Molecular pathology ABCB11 mutations cause a type of progressive
familial intrahepatic cholestasis of early (infancy) onset.

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Reem Bin Karam, Director of NAMA Women Advancement Establishment, highlighted the importance of field visits for BSEP participants.

How to be a successful businesswoman in the UAE?

ABCB11 gene polymorphism and BSEP dysfunction were also involved in a variety of cholestatic disorders, including intrahepatic cholestasis of pregnancy (ICP), which manifested in the last trimester of pregnancy, and characterized by raised serum bile acid levels (17).

Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: Role of ABCB11 genotype polymorphism and plasma bile acid levels

UDCA stimulates hepatic BSEP, and also co-stimulates hepatic, intestinal, and renal MRP2.

A Push-Catch System That Enables Effective Detoxification

Being [[sup.18]F]LCATD a substrate of the pharmacologically relevant hepatic transporter OATP1B1, as well as of transporters that are normally involved in the uptake and clearance of bile acids (such as NTCP and BSEP), if the coadministration of a drug affects the biodistribution of [[sup.18]F]LCATD, then there are high chances that the drug could cause DDIs or possibly drug induced hepatoxicity.

Preclinical Evaluation of [[sup.18]F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

BSEP, encoded by ABCB11, is responsible for the ATP-dependent transport of predominantly monovalent conjugated BS across the hepatocyte canalicular membrane.

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

MDR1, BSEP, BCRP, and MRP2 all have polymorphisms that have been associated with idiosyncratic ADRs.

Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays

In this study, we found that GW4064, a typical FXR activator, causes significant increases in the mRNA levels of phase II conjugation enzymes and phase III transporters, including glutathione S-transferases (GSTs) (Gst[alpha]3 and Gst[alpha]4), as well as of GSH metabolism-related genes (Gclm, Gpxl), glucuronosyltransferase (Ugtlal), sulfotransferases (Sultlal) (phase II), and efflux transporters (Mrp2 and Bsep) (phase III), which is consistent with the findings reported by Lee et al.

Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity

Bile salt export pump (BSEP) is a liver-specific ATP-binding cassette transporter encoded by the ABCB11 gene, which is expressed exclusively in the liver canalicular membrane and involved with bile acid transport.

Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma

Transport by vesicles of glycine-and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.

Persistent organic pollutants modify gut microbiota-host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

La colestasis 1 (CIFP1), enfermedad intrahepatica familiar, cuya fisiopatologia esta aun bajo investigacion; corresponde a una enfermedad de la bomba de exportacion (BSEP) que resulta en un defecto en la excrecion canalicular de acidos biliares secundaria a una mutacion en el gen ABCB11.

COLESTASIS INTRAHEPATICA FAMILIAR PROGRESIVA

Progressive familial intrahepatic cholestasis type II (PFIC II) occurs due to a number of different mutations in the BSEP gene, which encodes an ATP-binding cassette transporter involved in the salt export pump for the canalicular excretion of bile salts.

The membrane associated RING-CH proteins: a family of E3 ligases with diverse roles through the cell

Bile salt export pump (BSEP) is the predominant bile salt efflux system of hepatocytes.

The association between bile salt export pump single-nucleotide polymorphisms and primary biliary cirrhosis susceptibility and ursodeoxycholic acid response