Reem Bin Karam, Director of NAMA Women Advancement Establishment, highlighted the importance of field visits for
BSEP participants.
ABCB11 gene polymorphism and
BSEP dysfunction were also involved in a variety of cholestatic disorders, including intrahepatic cholestasis of pregnancy (ICP), which manifested in the last trimester of pregnancy, and characterized by raised serum bile acid levels (17).
UDCA stimulates hepatic
BSEP, and also co-stimulates hepatic, intestinal, and renal MRP2.
Being [[sup.18]F]LCATD a substrate of the pharmacologically relevant hepatic transporter OATP1B1, as well as of transporters that are normally involved in the uptake and clearance of bile acids (such as NTCP and
BSEP), if the coadministration of a drug affects the biodistribution of [[sup.18]F]LCATD, then there are high chances that the drug could cause DDIs or possibly drug induced hepatoxicity.
BSEP, encoded by ABCB11, is responsible for the ATP-dependent transport of predominantly monovalent conjugated BS across the hepatocyte canalicular membrane.
MDR1,
BSEP, BCRP, and MRP2 all have polymorphisms that have been associated with idiosyncratic ADRs.
In this study, we found that GW4064, a typical FXR activator, causes significant increases in the mRNA levels of phase II conjugation enzymes and phase III transporters, including glutathione S-transferases (GSTs) (Gst[alpha]3 and Gst[alpha]4), as well as of GSH metabolism-related genes (Gclm, Gpxl), glucuronosyltransferase (Ugtlal), sulfotransferases (Sultlal) (phase II), and efflux transporters (Mrp2 and
Bsep) (phase III), which is consistent with the findings reported by Lee et al.
Bile salt export pump (
BSEP) is a liver-specific ATP-binding cassette transporter encoded by the ABCB11 gene, which is expressed exclusively in the liver canalicular membrane and involved with bile acid transport.
Transport by vesicles of glycine-and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human
BSEP with rat
Bsep.
Progressive familial intrahepatic cholestasis type II (PFIC II) occurs due to a number of different mutations in the
BSEP gene, which encodes an ATP-binding cassette transporter involved in the salt export pump for the canalicular excretion of bile salts.
Bile salt export pump (
BSEP) is the predominant bile salt efflux system of hepatocytes.