ABCB11

(redirected from BRIC2)

ABCB11

A gene on chromosome 2q24 that encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, MDR/TAP subfamily, which is involved in multi-drug resistance and is major canalicular bile salt export pump
Molecular pathology ABCB11 mutations cause a type of progressive
familial intrahepatic cholestasis of early (infancy) onset.
References in periodicals archive ?
Except for PFIC2, mutations in ABCB11 may result in a milder nonprogressive form of PFIC2 known as BRIC2 as well as other forms of cholestasis such as ICP and/or drug-induced cholestasis (see below).
There are two genetically characterised forms of BRIC: BRIC1 (Summerskill-Walshe-Tygstrup syndrome, OMIM #243300) and BRIC2 (OMIM #605479), caused by partial deficiency in ATP8B1 [39, 73] and ABCB11 [74], respectively.
Pickering Interfaces introduced its BRIC2 matrices that occupy two slots of a PXI chassis, providing a more compact system for matrix applications not requiring the higher crosspoint count of four--or eight-slot BRICs.