BRCA1

(redirected from BRCAI)
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BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.
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BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
sister carries the BRCAi gene and getting fired because your sister has
A little scientific summary of the technology in discussion: The test Jolie received works by screening for mutations in an individual's BRCAI and BRCA2 genes.
1994 The complete sequence of BRCAI gene is identified, including specific mutations related to hereditary breast and ovarian cancer, by a collaborative effort led by Mark Skolnick at the University of Utah Medical Center.
Contribution of BRCAI and BRCA2 mutations to breast and ovarian cancer in Pakistan.
Without introns, the BRCAI gene is even smaller: approximately 5,500 nucleotides long.
See also Stiglitz & Sulston, supra note 1, at A19 ("Myriad had total control over the BRCAI and BRCA2 genes since the 1990s.
The District Court of the Southern District of New York issued a recent opinion overturning patents on the isolated BRCAI and BRCA2 genes.
This paper reports on women with proven inherited disease-predisposing BRCAI and BRCA2 mutations participating in the Prevention and Observation of Surgical Endpoints (PROSE) consortium multicentre study, who were ascertained to carry the high-risk predisposition gene between 1974 and 2008 [1].
If she is found to carry a brcai or 2 mutation, her doctors will encourage her to have the other one removed to prevent reoccurrence.
A strong candidate for the breast and ovarian cancer susceptibility gene BRCAI. Science 1994; 266 : 66-71.
(17) A positive test result for breast cancer type 1 (BRCAI) or breast cancer type 2 (BRCA2) for example, can indicate that an individual has a greater than average risk of developing breast cancer.