Loss of BRCA1-associated Protein 1
(BAP1) expression is rare in non-small cell lung cancer.
Epizyme announced the first detailed results from the Phase 2 study of its lead candidate tazemetostat, a potent, selective, orally available EZH2 inhibitor, in relapsed/refractory malignant mesothelioma patients with BRCA1-associated protein 1
Fisogni et al., "BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations," Modern Pathology, vol.
Wang et al., "Prognostic significance of BRCA1-associated protein 1 in colorectal cancer," Medical Oncology, vol.
BAP1 is short for BRCA1-associated protein 1
. As it happens, BRCA1 is linked to breast cancer in some women.
Recent discoveries indicate that ASTs represent a genetically heterogeneous group of tumors, including those with BAP1 (BRCA1-associated protein 1
) loss, ALK (anaplastic lymphoma kinase) fusion, or homozygous CDKN2A loss.
BRCA1-associated protein 1
(BAP1) is a nuclear ubiquitin hydrolase that is believed to function as a tumor suppressor.
(%) Nasu et al, (31) 2015 (a) 9/16 (56) 5/8 (63) Farzin et al, (36) 2015 19/42 (45) 12/67 (18) Yoshikawa et al, (37) 2012 1/5 (20) Sheffield et al, (39) 2015 (b) 2/12 (15) Cigognetti et al, (38) 2015 9/15 (60) 2/13 (15) Abbreviation: BAP1, BRCA1-associated protein 1
. (a) A few tumors showed a mixture of cells with BAP1 loss and BAP1 retention.