BRCA1

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Related to BRCA1 protein: BRCA gene

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters.
Elsa Suberbielle, D.VM., Ph.D., of Gladstone Institute of Neurological Disease, San Francisco, and her colleagues found low levels of BRCA1 protein, a DNA repair enzyme, in the brains of deceased Alzheimer's and mild cognitive impairment patients, compared with controls, as well as in mouse models of Alzheimer's.
Research suggests that the BRCA1 protein also regulates the activity of other genes and plays a critical role in embryonic development.
Claim 1 of the patent is for a specific isolated DNA (called SEQ ID NO: 2) coding for the BRCA1 protein, while Claim 5 of the patent is for an isolated DNA with at least fifteen nucleotides of SEQ ID NO: 2.
Investigators have found that one of the key abnormalities in the basal-like carcinomas is a reduction of BRCA1 protein and messenger RNA levels.
Increased BRCA1 protein in mammary tumours of rats fed marine omega- 3 fatty acids.
A study in mice now suggests one possibility: The BRCA1 protein moderates the hormone progesterone's effect in breast cells.
BRCA1 protein is linked to the RNA polymerase II holoenzime complex via RNAhelicase A.
Expression of BRCA1 protein in breast cancer and its prognostic significance.
"These findings add weight to the suggestion that a lack of BRCA1 protein may have important consequences in nonhereditary breast cancer."
The experiment clearly shows that both BRCA1 alleles are equally retained in the tumor, indicating that 3238 [right arrow] A (which produces a nonconservative S1040N amino acid change in the BRCA1 protein) is not a deleterious BRCA1 mutation and must be considered a nonpathogenic rare polymorphism.