BRCA1

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Related to BRCA1 protein: BRCA gene

BRCA1

symbol for a breast cancer gene. BRCA1 is a tumor suppressor gene. A healthy BRCA1 gene produces a protein that protects against unwanted cell growth. The protein is packaged by the cell's Golgi apparatus into secretory vesicles, which release their contents on the cell's surface. The protein circulates in the intracellular space, attaching itself to neighboring cell receptors. The receptors signal the cell nuclei to stop growing. When the gene is defective, it produces a faulty protein that is unable to prevent proliferation of abnormal cells as they evolve into potentially deadly breast cancer. BRCA1 may also normally inhibit ovarian cancer.

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters.
of Gladstone Institute of Neurological Disease, San Francisco, and her colleagues found low levels of BRCA1 protein, a DNA repair enzyme, in the brains of deceased Alzheimer's and mild cognitive impairment patients, compared with controls, as well as in mouse models of Alzheimer's.
Research suggests that the BRCA1 protein also regulates the activity of other genes and plays a critical role in embryonic development.
Therefore, Claim 5 covers any isolated DNA that codes for the BRCA1 protein and has at least ~.
15) Expression of this gene is very low in ER+ breast carcinomas but is up-regulated in invasive, ER2 carcinomas, especially those with medullary features and decreased BRCA1 protein levels.
Increased BRCA1 protein in mammary tumours of rats fed marine omega- 3 fatty acids.
A study in mice now suggests one possibility: The BRCA1 protein moderates the hormone progesterone's effect in breast cells.
BRCA1 protein is linked to the RNA polymerase II holoenzime complex via RNAhelicase A.
During pregnancy, when breast cells are proliferating rapidly, hormones induce cells to make extra BRCA1 protein to keep cell growth from running out of control, scientists said.
5,750,400) were each for a full-length coding sequence of the BRCA1 gene, which encodes for the "normal" or "healthy" BRCA1 protein.
Expression of BRCA1 protein in breast cancer and its prognostic significance.