BRCA1

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Related to BRCA1 protein: BRCA gene

BRCA1

symbol for a breast cancer gene. BRCA1 is a tumor suppressor gene. A healthy BRCA1 gene produces a protein that protects against unwanted cell growth. The protein is packaged by the cell's Golgi apparatus into secretory vesicles, which release their contents on the cell's surface. The protein circulates in the intracellular space, attaching itself to neighboring cell receptors. The receptors signal the cell nuclei to stop growing. When the gene is defective, it produces a faulty protein that is unable to prevent proliferation of abnormal cells as they evolve into potentially deadly breast cancer. BRCA1 may also normally inhibit ovarian cancer.

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
Because certain breast and nerve cells mature from the same type of embryonic cells, Koller suggests that the BRCA1 protein may help both cell types mature.
The University of California patent covers a number of BRCA1 gene mutations, but does not cover a full-length coding sequence of the gene, which is required to make the BRCA1 protein.
The team led by Mary-Claire King of the University of California, Berkeley, found a mutation that causes a similar mistake in the zinc-finger region of the BRCA1 protein.
Preliminary data suggests that the BRCA1 protein may act as an extracellular tumor suppressor which, if established, could make the BRCA1 protein a promising new anti-breast cancer drug candidate.
15) Expression of this gene is very low in ER+ breast carcinomas but is up-regulated in invasive, ER2 carcinomas, especially those with medullary features and decreased BRCA1 protein levels.
Earlier research had shown that BRCA1 protein orchestrates the repair of damaged DNA.
The study indicates the Brca1 protein monitors cell-cycle checkpoints at both the DNA replication (S-phase) and mitosis, or cell division, (G2/M) stages.
The BRCA1 protein treatment halted or shrank the resulting tumors and lengthened the animals' lives, said the researchers.
5,750,400) were each for a full-length coding sequence of the BRCA1 gene, which encodes for the "normal" or "healthy" BRCA1 protein.
Expression of BRCA1 protein in breast cancer and its prognostic significance.
The BRCA1 protein is produced in normal cells, but cancer cells have found a way to make less of this beneficial protein, in part by using the ID4 gene.
These findings add weight to the suggestion that a lack of BRCA1 protein may have important consequences in nonhereditary breast cancer.