BRCA1 gene


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Related to BRCA1 gene: BRCA2 gene, BRCA2

BRCA1 gene

a tumor suppressor gene on chromosome 17 at locus 17q21, isolated in 1994; carriers of germline mutations in BRCA1 are predisposed to develop both breast and ovarian cancer.
See also: BRCA2 gene, carcinoma of the breast.

BRCA1 gene

(jēn)
A tumor suppressor gene on chromosome 17 at locus 17q21, isolated in 1994; encodes p53 protein, which prevents cells with damaged DNA from dividing; carriers of germline mutations in BRCA1 are predisposed to develop both breast and ovarian cancer.
See also: BRCA2 gene, carcinoma of the breast

BRCA1 gene

A breast cancer gene found in a small percentage of patients with this malignancy, and carried by some individuals who will develop breast cancer later in life.

Patient care

BRCA1 Gene Mutation: Patient care focuses on determining the family history of the patient and referral to a genetic counselor with expertise in this mutation when appropriate.

See also: gene
References in periodicals archive ?
The data also illustrate why rare variations in the BRCA1 gene are not always mutations that put women and men at high risk for specific cancers.
Ten primers of all ten exons of COX-2 gene (coding region) and primers for 5' (exon numbers 1, 2 and 12) and 3' region (exon numbers 18, 19, 20, 21 and 22) of BRCA1 gene were designed by primer 3 software (Tables II, IV) and these PCR reactions were optimized by using different amounts of MgCl2, dNTPs, buffer, primers and DNA (Tables III, V).
Five months of chemotherapy followed and, in March 2013, it was confirmed Iona was carrying the BRCA1 gene which greatly increases the risk of breast and ovarian cancer.
Primers for COX-2 gene (10 exons, all the coding region) and primers for 5' (exon numbers 1, 2 and 12) and 3' region (exon numbers 18, 19, 20, 21 and 22) of BRCA1 gene were designed by primer 3 software.
The tests showed that she did, indeed, carry the BRCA1 gene mutation: "My gut instinct had proved right.
5117G>C identified in BRCA1 gene had been detected in Algerian and Moroccan populations [16, 17] but it was reported as an unclassified variant.
Andrea's two daughters, Amelia, 16, and Eli, 22, face the agonising choice of whether to find out if they too carry the BRCA1 gene mutation.
Someday soon, drugs--rather than surgical removal of breasts and ovaries--could avert cancer in women carrying the BRCA1 gene.
A woman with the BRCA1 gene has an 85% risk of developing breast cancer, leading some carriers to take the drastic step of breast removal.
27 June 2014 - Researchers from University College London have discovered an epigenetic signature in women with a mutated BRCA1 gene that was associated with higher risk of developing breast cancer and lower survival rates.
His tool exhibits an 81 percent accuracy rate and could be used to more accurately identify cancer threats from BRCA1 gene mutations.