BRCA1 gene


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Related to BRCA1 gene: BRCA2 gene, BRCA2

BRCA1 gene

a tumor suppressor gene on chromosome 17 at locus 17q21, isolated in 1994; carriers of germline mutations in BRCA1 are predisposed to develop both breast and ovarian cancer.
See also: BRCA2 gene, carcinoma of the breast.

BRCA1 gene

(jēn)
A tumor suppressor gene on chromosome 17 at locus 17q21, isolated in 1994; encodes p53 protein, which prevents cells with damaged DNA from dividing; carriers of germline mutations in BRCA1 are predisposed to develop both breast and ovarian cancer.
See also: BRCA2 gene, carcinoma of the breast

BRCA1 gene

A breast cancer gene found in a small percentage of patients with this malignancy, and carried by some individuals who will develop breast cancer later in life.

Patient care

BRCA1 Gene Mutation: Patient care focuses on determining the family history of the patient and referral to a genetic counselor with expertise in this mutation when appropriate.

See also: gene
References in periodicals archive ?
We found that 2% (25/1262) of Turkish patients with a family history of breast and ovarian cancer had rearrangements in the BRCA1 gene. Sixteen rearrangements were observed in patients with breast cancer with a frequency of 64% (16/25).
Among her main avenues of research is the BRCA1 gene, which--when abnormal--predisposes women to breast and ovarian cancer.
In the majority of benign tumors and more especially of malignant tumors, the BRCA1 gene expression has been observed and an increase in cytoplasmic expression, while a decrease in nuclear expression was observed (Fustier et al., 2003).
This newly defined risk, the first to show a conclusive link between the BRCA1 gene mutation and a small but significant chance of developing an aggressive uterine cancer, could become a consideration in weighing treatment options.
Primers for COX-2 gene (10 exons, all the coding region) and primers for 5' (exon numbers 1, 2 and 12) and 3' region (exon numbers 18, 19, 20, 21 and 22) of BRCA1 gene were designed by primer 3 software.
Finally, one large genomic rearrangement was identified in BRCA1 gene: del exon 2 results in a deletion of exon 2, which includes the BRCA1 translation start codon, it is also known as BRCA1 c.(-19-?)_(80+?)del.
According to a study published online April 23, 2015 in the journal JAMA Oncology, for breast cancer patients who have the BRCA1 gene mutation, undergoing an oophorectomy (a procedure that removes a woman's ovaries) reduced breast cancer death rates by 62 percent.
The budding singer-songwriter took the decision to have a double mastectomy after doctors told her she had a harmful mutation in her BRCA1 gene.
The actress carries a mutation in the BRCA1 gene meaning she had a 50% chance of developing ovarian cancer, which killed her mother, Marcheline Bertrand, in 2007.
Writing in The New York Times, the mother, who carries a mutation in the BRCA1 gene, said the decision was "not easy".
IN MAY 2013, ANGELINA JOLIE took a genetic test that identified an abnormality in her BRCA1 gene, which put her at great risk for developing breast cancer.
Someday soon, drugs--rather than surgical removal of breasts and ovaries--could avert cancer in women carrying the BRCA1 gene. Researchers from Northern Ireland have confirmed that this gene prevents cells from fighting the high levels of estrogen present in every woman's ovaries and breasts, and that the unchecked estrogen leads to DNA damage resulting in extreme cancer susceptibility.