BRCA1 downregulation

BRCA1 downregulation

The reduction in BRCA1 (Breast Cancer Susceptibility Protein-1), which impedes DNA repair and commonly occurs in sporadic breast cancers. BRCA1 downregulation is associated with intraductal carcinoma, basal-like and triple-negative carcinomas and ID4 overexpression, and correlates with poor prognosis.
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