BRCA1


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Related to BRCA1: BRCA2

BRCA1

symbol for a breast cancer gene. BRCA1 is a tumor suppressor gene. A healthy BRCA1 gene produces a protein that protects against unwanted cell growth. The protein is packaged by the cell's Golgi apparatus into secretory vesicles, which release their contents on the cell's surface. The protein circulates in the intracellular space, attaching itself to neighboring cell receptors. The receptors signal the cell nuclei to stop growing. When the gene is defective, it produces a faulty protein that is unable to prevent proliferation of abnormal cells as they evolve into potentially deadly breast cancer. BRCA1 may also normally inhibit ovarian cancer.

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
Compared with non-demented controls, neuronal BRCA1 levels in the patients were reduced by 65-75%.
A small percentage of patients (about 5%) who undergo genetic testing for BRCA1 and BRCA2 receive a variant of uncertain significance (VUS) result, indicating a genetic sequence change with an unknown association with cancer risk.
Why do non-Jews in the Southwest have BRCA1 and BRCA2 gene mutations?
BRCA1 modulates malignant cell behavior, the expression of survivin and chemosensitivity in human breast cancer cells.
The pedigrees of these three groups of families were compared to determine the respective contribution of BRCA1 and BRCA2 to breast and ovarian cancer and to establish which other cancers may be associated with mutations in these genes.
We report the identification and characterization of allele-specific splicing (ASS) linked to the nonpathogenic BRCA1 variant c.
As we shall see, histology is also of utmost importance in driving the decision to test for BRCA1.
Attempts to adjust for ascertainment bias has resulted in lower overall risks being estimated for BRCA1 and BRCA2 [20], especially when these studies include population-based series [21].
Increased BRCA1 protein in mammary tumours of rats fed marine omega- 3 fatty acids.
A paper in the 15 August 2006 issue of Cancer Research now gives the clearest picture to date of how many people in the United States carry mutations in the two dominant "breast cancer genes," BRCA1 and BRCA2.
Carriers of BRCA1 or BRCA2 gene mutations have an increased risk of ovarian cancer, cancer of the fallopian tubes, and primary peritoneal cancer.
The BRCA1(omi4) sequence is used for identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because the patient has an inherited causative mutation in their BRCA1 gene.