BRCA1


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Related to BRCA1: BRCA2

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
Selection criteria was formulated by careful examination of data from previous studies about analysis of BRCA1 mutations at exon-2.
Among 872 participating BRCA1 carriers, 43% (n = 377) used HT following BO.
We searched for patients at high-risk of breast and ovarian cancer across seven different regions of Turkey in order to evaluate the prevalence and spectrum of rearrangements of BRCA1 and BRCA2 genes.
Como resultado del modelo se deberia escoger la combinacion de mastectomia bilateral y cirugia reductora de riesgo en trompas y ovarios como medida para prevenir el cancer de mama y ovario en mujeres con mutacion del gen BRCA1 con el umbral propuesto por la OMS para la region.
The normal function of BRCA1 and BRCA2 genes is DNA repair, transcription and recombination, all of which prevent cancer development as part of the tumor suppressor group of genes.
The study discovered that, although the mutations had not been inherited, many breast cancer patients had mutational signatures that were identical to those with faulty BRCA1 and BRCA2 genes.
Among her main avenues of research is the BRCA1 gene, which--when abnormal--predisposes women to breast and ovarian cancer.
COX-2, BRCA1, feline, mammary tumor, gene expression
El BRCA1 se expresa en distintos epitelios del organismo durante el desarrollo; y su expresion se ve aumentada durante el embarazo y disminuye tras el parto.
Currently, women with the BRCA1 mutation often have preventive surgeries to remove both breasts, as well as their ovaries and fallopian tubes, based on studies showing that the gene mutation elevates their risk for cancers in those organs.
Although instability in the estimated magnitude of this risk remains, we believe that the possibility of this cancer should be considered when discussing the advantages and risks of hysterectomy at the time of RRSO in BRCA1 + women," they wrote.
The NEXTflex BRCA1 and BRCA2 Amplicon Panels are complete kits that include all components necessary for rapidly generating ready-to-sequence libraries, including primer pairs, library prep reagents, size selection beads, and indexed barcodes.