BRCA1

(redirected from BRCA gene)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to BRCA gene: BRCA2 gene, Lynch syndrome

BRCA1

symbol for a breast cancer gene. BRCA1 is a tumor suppressor gene. A healthy BRCA1 gene produces a protein that protects against unwanted cell growth. The protein is packaged by the cell's Golgi apparatus into secretory vesicles, which release their contents on the cell's surface. The protein circulates in the intracellular space, attaching itself to neighboring cell receptors. The receptors signal the cell nuclei to stop growing. When the gene is defective, it produces a faulty protein that is unable to prevent proliferation of abnormal cells as they evolve into potentially deadly breast cancer. BRCA1 may also normally inhibit ovarian cancer.

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
The fast-tracked approval of Lynparza was based on a trial of 302 women with metastatic breast cancer and a BRCA gene mutation.
Normal cells expressing one copy of the BRCA gene would have a way to repair, and have a functional repair pathway if they do face an obstacle.
In a 2013 study sponsored by the AHRQ and CDC, Moorman and colleagues performed a meta-analysis to examine the potential contribution of BRCA gene mutations to the risk of breast cancer among OC users.
This will surely have profound implications for future developments and innovation that will reach much further than the limited context of Myriad's BRCA gene patents.
But the fact that the Court upheld some of Myriad's patents on the BRCA gene sequences has made the situation less simple than it first appeared.
Called the BRCA Babes, the women in the calendar all have the mutated BRCA gene, which leaves them at a higher risk of breast or ovarian cancer.
The genetics section focused on the BRCA gene, which affects one in four Ashkenazi Jew, making it an important issue for Moment to cover.
While many hailed Jolie as brave for the preventive surgery against the BRCA gene, which she carries, Etheridge called Jolie's decision a "fearful choice," saying that she believes cancer is a result of stress, nutrition and environment.
For 15 years Myriad's patents had given it a monopoly on BRCA gene testing in the United States, limiting the availability of the test and making it impossible for some patients to obtain a second opinion on their results.
But surgeon Julie Margenthaler, who has studied breast cancer in young women at the Washington University School of Medicine in St Louis, said the new study was limited by a lack of data on women's family history, including which ones were carriers of BRCA gene mutations.
The argument that Antonia and Julie make in favour of the pregnancy hinges on the fact the BRCA gene could mean a premature hysterectomy for Antonia, depriving her of another chance to have a baby - like her sister, Jasmine.
Rather than hoping she would pass on her mutation-negative copy of the BRCA gene, resulting in a mutation-negative child, this participant discussed the concern that she would mar her partner's healthy genetic line if she produced a BRCA 1/2-positive child.