BRCA


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BRCA

n.
Either of two tumor suppressor genes (BRCA1 or BRCA2) that are associated with an increased risk of developing familial breast and ovarian cancer when inherited in a mutated state.
References in periodicals archive ?
Approximately 20 to 25% of patients with hereditary breast cancers and up to 10% of patients with any type of breast cancer have a BRCA mutation.
According to ACT Genomics, its ACTBRCA testing is selected to serve the phase III trial sponsored by AstraZeneca Taiwan on germline BRCA testing of patients with HER2 negative metastatic breast cancer.
POSH is believed to be the largest prospective cohort study to compare breast cancer outcomes for patients with BRCA mutations to those with sporadic breast cancer.
In a subgroup of women with triple-negative breast cancer, those with a BRCA mutation had slightly higher survival rates for the first two years after diagnosis.
BRCA proteins are known for their role in repairing double strand breaks.
The BRCA gene can also increase the risk of men getting prostate cancer and both sexes developing pancreatic cancer.
Reports say not everyone who carries these genetic mutations will develop cancer, but studies suggest that more cancers may arise from BRCA or BRCA-like mutations.
Prof Workman said: "We remain disappointed that women with ovarian cancer and mutations to their BRCA genes are still not being granted this world-first drug on the NHS.
A LOT OF PEOPLE rushed to get BRCA [gene] testing after Angelina Jolie, and then they thought they were out of the woods:' says Sarasota Memorial genetics education program coordinator Cathy McCann.
Besides their tart, tangy pungent taste, the cultivar concord grapes' the flavonoid and phytochemical rich berries have been proven to prevent this leading cause of worldwide morbidity and mortality in women as a third of women, suffering from cancers suffer from BRCA.
The results suggest that in the future, patients with squamous cell lung cancer could benefit from drugs specifically designed to be effective in cancers with BRCA mutations.