BRAF


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BRAF

A gene on chromsome 7q34 that encodes a protein of the raf/mil family of serine/threonine protein kinases, which plays a role in regulating the MAP kinase/ERKs-signalling pathway, affecting cell division, differentiation and secretion.

Molecular pathology
BRAF mutations are associated with cardiofaciocutaneous syndrome, which is characterised by heart defects, mental retardation and a distinctive facial appearance. Acquired BRAF mutations have been linked to non-Hodgkin lymphoma, colorectal cancer, melanoma, thyroid carcinoma, non-small cell lung carcinoma and adenocarcinoma of lung.
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References in periodicals archive ?
Recent recommendations listed 2 sets of tests: a set of essential tests (EGFR, ALK, ROS1) that can be used to direct therapy and an optional set (BRAF, RET, MET, HER2, KRAS) that can be used to direct patients toward clinical trials.
On multivariable analysis, V600E, but not non-V600E, BRAF mutation was correlated with worse overall survival and disease-free survival (hazard ratios, 2.76 and 2.04, respectively).
Here, we report on the results of a large-scale translational melanoma study with the primary aim of investigating the practicality of ctDNA analysis and its viability to serve as an alternative to tissue-based testing to assess BRAF mutation status.
Similar to BRAF status and PD1 expression, there is conflicting evidence regarding survival benefit based on LDH level in patient treated with checkpoint inhibitors [8, 9, 11, 12].
Ideas for new treatment options for BRAF-mutated CRCs concentrate on targeting the BRAF mutation because this mutation is blamed for the bad prognosis.
Mutations in the KRAS (exons 2, 3, and 4), NRAS (exons 2, 3, and 4), HRAS (exon 2), and BRAF (exon 15) of each tumor specimen were examined.
Our attempt was to study the frequency of BRAF mutation in various thyroid diseases.
The data collection used consisted of n = 291 samples for which both histopathology whole-slide images and clinical data (including BRAF and KRAS mutation status) were available, along with gene expression necessary for computing the BRAF score [8].
The B-type Raf proto-oncogene (BRAF) encodes an enzyme that takes part in intracellular signaling and cell growth, and BRAF mutation has been frequently observed in CRC, supporting its role in tumorigenesis [4,17].