POU2AF1

(redirected from BOB1)

POU2AF1

A gene on chromosome 11q23.1 that encodes a transcription coactivator that recognises the POU domains of OCT1 and OCT2, boosting OCT1 mediated promoter activity and, to a lesser extent, that of OCT2. POU2AF1 is essential for B-cell response to antigens and required for germinal centre formation.
References in periodicals archive ?
The single slide test aids the assessment of nine antibodies, namely CD30, CD15, CD20, CD45, PAX5, OCT2, BOB1, CD3 and CD79A, on a single formalin fixed paraffin embedded tissue section.
19) Most cases also strongly express the B-cell transcription factors BOB1 and OCT2.
The large B cells are positive for pan-B-cell antigens including CD19, CD20, CD79a, PAX5, OCT2, and BOB1 with expression of CD45.
In comparing CHL and PMLBCL, Hoeller et al (72) suggest that expression of BOB1 favors PMLBCL and expression of cyclin E favors CHL.
In most cases, HRS cells are characteristically positive for CD15 and CD30, with membranous staining and punctate accentuation in the Golgi area; they are also (weakly) reactive for PAX5 and either OCT2 or BOB1 (not both).